Linked Life Data

10873711

Source:http://linkedlifedata.com/resource/pubmed/id/10873711

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2000-8-8
pubmed:abstractText
Based on the hypothesis that tissue partitioning of volatile organic compounds (VOCs) is due to lipophilic and hydrophilic interactions with tissue components, empirical relations are established between olive oil (P(oil:air)), saline (P(saline:air)), and tissue partition coefficients (P(tissue:air)) for human and rat tissues. Reported values of partition coefficients of a wide range of VOCs with distinct chemical structures (n = 137) have been compiled from the literature. Bilinear regression analysis shows that partition coefficients of VOCs in human blood, brain, fat, liver, kidney, and muscle tissues are well described by a linear combination of P(oil:air) and P(saline:air) with tissue-specific regression coefficients. The regression coefficient associated with the hydrophilic component of VOC partitioning in rat tissues is systematically higher than that of human tissues. For the human model, tissue concentrations calculated from predicted partition coefficients are generally within a factor 4 of tissue concentrations calculated from experimentally observed partition coefficients. These results demonstrate that, without prior knowledge of tissue composition, it is possible to obtain estimates of human tissue partition coefficients of VOCs with an accuracy that is in the same range as that commonly used in risk assessment.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0041-008X
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
165
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
206-16
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Empirical relations predicting human and rat tissue:air partition coefficients of volatile organic compounds.
pubmed:affiliation
Research Institute of Toxicology, Utrecht University, The Netherlands.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't