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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2000-8-17
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pubmed:abstractText |
Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease believed to be caused by an inflammatory process in the pancreas leading to selective destruction of the beta cells. Inducible cyclooxygenase (COX-2) is expressed under inflammatory conditions and its product prostaglandin E(2) (PGE(2)) is an important inflammation mediator. We report here that administration of the selective COX-2 inhibitor NS-398 prevents the onset of diabetes in mice brought on by multiple low-doses of streptozotocin (STZ). Histological observations indicated that STZ-mediated destruction of beta cells was prevented by NS-398 treatment. Delayed (day 3) administration of NS-398 was also protective in this model. No protective effect was observed when NS-398 was administered prior to a high, toxic dose of STZ. These results demonstrate the critical importance of COX-2 activity in autoimmune destruction of beta cells, and point to the fact that COX-2 inhibition can potentially develop into a preventive therapy against IDDM.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2 Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/Hemoglobin A, Glycosylated,
http://linkedlifedata.com/resource/pubmed/chemical/Indomethacin,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/N-(2-cyclohexyloxy-4-nitrophenyl)met...,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrobenzenes,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/Streptozocin,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2000 Academic Press.
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
273
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
699-704
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10873667-Animals,
pubmed-meshheading:10873667-Blood Glucose,
pubmed-meshheading:10873667-Cyclooxygenase 2,
pubmed-meshheading:10873667-Cyclooxygenase 2 Inhibitors,
pubmed-meshheading:10873667-Cyclooxygenase Inhibitors,
pubmed-meshheading:10873667-Diabetes Mellitus, Experimental,
pubmed-meshheading:10873667-Diabetes Mellitus, Type 1,
pubmed-meshheading:10873667-Dinoprostone,
pubmed-meshheading:10873667-Hemoglobin A, Glycosylated,
pubmed-meshheading:10873667-Indomethacin,
pubmed-meshheading:10873667-Isoenzymes,
pubmed-meshheading:10873667-Male,
pubmed-meshheading:10873667-Mice,
pubmed-meshheading:10873667-Mice, Inbred BALB C,
pubmed-meshheading:10873667-Nitrobenzenes,
pubmed-meshheading:10873667-Pancreas,
pubmed-meshheading:10873667-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:10873667-Streptozocin,
pubmed-meshheading:10873667-Sulfonamides,
pubmed-meshheading:10873667-Time Factors
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pubmed:year |
2000
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pubmed:articleTitle |
COX-2 inhibition prevents insulin-dependent diabetes in low-dose streptozotocin-treated mice.
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pubmed:affiliation |
Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, 825 N. E. 13th Street, Oklahoma City, Oklahoma 73104, USA. Tahereh-Tabatabaie@omrf.ouhsc.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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