| pubmed-article:10873589 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10873589 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:10873589 | lifeskim:mentions | umls-concept:C0017759 | lld:lifeskim |
| pubmed-article:10873589 | lifeskim:mentions | umls-concept:C0085144 | lld:lifeskim |
| pubmed-article:10873589 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10873589 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:10873589 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:10873589 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10873589 | pubmed:dateCreated | 2000-7-27 | lld:pubmed |
| pubmed-article:10873589 | pubmed:abstractText | Autocrine motility factor (AMF) is identical to the glycolytic enzyme phosphohexose isomerase (PHI) and overexpression of AMF/PHI is associated with tumor malignancy. In order to study the overexpression of AMF/PHI, an HA-tagged AMF construct was transiently transfected into Cos7 cells. Expression of a tagged AMF-HA allowed us to determine that over a period of 16 hours only a small amount (0.1-1%) of total cellular AMF-HA was secreted into the cell medium. Cell-associated AMF-HA was exclusively cytosolic as it could be completely extracted with Triton X-100 and concentrated within actin rich pseudopodial domains. Treatment of the cells with the glycolysis inhibitor oxamate disrupted the association of AMF-HA with actin concentrations demonstrating that glycolysis regulates the formation of these AMF/PHI-associated actin-rich protrusions. AMF/PHI is a well-characterized tumor cell secreted cytokine and we identify here an alternate intracellular function for this glycolytic enzyme/cytokine in cell motility. | lld:pubmed |
| pubmed-article:10873589 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10873589 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10873589 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10873589 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10873589 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10873589 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10873589 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10873589 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10873589 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10873589 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10873589 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10873589 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10873589 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10873589 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:10873589 | pubmed:author | pubmed-author:RauLL | lld:pubmed |
| pubmed-article:10873589 | pubmed:author | pubmed-author:NabiI RIR | lld:pubmed |
| pubmed-article:10873589 | pubmed:author | pubmed-author:LaganaAA | lld:pubmed |
| pubmed-article:10873589 | pubmed:author | pubmed-author:DesGroseiller... | lld:pubmed |
| pubmed-article:10873589 | pubmed:author | pubmed-author:DuchaineTT | lld:pubmed |
| pubmed-article:10873589 | pubmed:copyrightInfo | Copyright 2000 Academic Press. | lld:pubmed |
| pubmed-article:10873589 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10873589 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:10873589 | pubmed:volume | 273 | lld:pubmed |
| pubmed-article:10873589 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10873589 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10873589 | pubmed:pagination | 213-8 | lld:pubmed |
| pubmed-article:10873589 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:10873589 | pubmed:meshHeading | pubmed-meshheading:10873589... | lld:pubmed |
| pubmed-article:10873589 | pubmed:meshHeading | pubmed-meshheading:10873589... | lld:pubmed |
| pubmed-article:10873589 | pubmed:meshHeading | pubmed-meshheading:10873589... | lld:pubmed |
| pubmed-article:10873589 | pubmed:meshHeading | pubmed-meshheading:10873589... | lld:pubmed |
| pubmed-article:10873589 | pubmed:meshHeading | pubmed-meshheading:10873589... | lld:pubmed |
| pubmed-article:10873589 | pubmed:meshHeading | pubmed-meshheading:10873589... | lld:pubmed |
| pubmed-article:10873589 | pubmed:meshHeading | pubmed-meshheading:10873589... | lld:pubmed |
| pubmed-article:10873589 | pubmed:meshHeading | pubmed-meshheading:10873589... | lld:pubmed |
| pubmed-article:10873589 | pubmed:meshHeading | pubmed-meshheading:10873589... | lld:pubmed |
| pubmed-article:10873589 | pubmed:meshHeading | pubmed-meshheading:10873589... | lld:pubmed |
| pubmed-article:10873589 | pubmed:meshHeading | pubmed-meshheading:10873589... | lld:pubmed |
| pubmed-article:10873589 | pubmed:meshHeading | pubmed-meshheading:10873589... | lld:pubmed |
| pubmed-article:10873589 | pubmed:meshHeading | pubmed-meshheading:10873589... | lld:pubmed |
| pubmed-article:10873589 | pubmed:meshHeading | pubmed-meshheading:10873589... | lld:pubmed |
| pubmed-article:10873589 | pubmed:meshHeading | pubmed-meshheading:10873589... | lld:pubmed |
| pubmed-article:10873589 | pubmed:meshHeading | pubmed-meshheading:10873589... | lld:pubmed |
| pubmed-article:10873589 | pubmed:meshHeading | pubmed-meshheading:10873589... | lld:pubmed |
| pubmed-article:10873589 | pubmed:meshHeading | pubmed-meshheading:10873589... | lld:pubmed |
| pubmed-article:10873589 | pubmed:meshHeading | pubmed-meshheading:10873589... | lld:pubmed |
| pubmed-article:10873589 | pubmed:meshHeading | pubmed-meshheading:10873589... | lld:pubmed |
| pubmed-article:10873589 | pubmed:meshHeading | pubmed-meshheading:10873589... | lld:pubmed |
| pubmed-article:10873589 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10873589 | pubmed:articleTitle | Expression of autocrine motility factor/phosphohexose isomerase in Cos7 cells. | lld:pubmed |
| pubmed-article:10873589 | pubmed:affiliation | Department of Pathology and Cell Biology, Université de Montréal, Montreal, Quebec, H3C 3J7, Canada. | lld:pubmed |
| pubmed-article:10873589 | pubmed:publicationType | Journal Article | lld:pubmed |
