|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2000-7-25
|
|
pubmed:abstractText |
Increased matrix metalloproteinase 2 expression and activity are associated with premature rupture of fetal membranes. A proapoptotic protein produced in response to deoxyribonucleic acid fragmentation, p53, can bind to the matrix metalloproteinase 2 gene promoter and cause increased gene expression. It promotes apoptosis by inducing the expression of the proapoptotic bax gene and inhibiting the antiapoptotic bcl-2 gene. This study was undertaken to investigate the expression pattern of apoptotic elements in pregnancy complications that may cause increased expression of the gene for matrix metalloproteinase 2.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0002-9378
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
182
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1468-76
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:10871467-Apoptosis,
pubmed-meshheading:10871467-DNA Fragmentation,
pubmed-meshheading:10871467-Enzyme Activation,
pubmed-meshheading:10871467-Extraembryonic Membranes,
pubmed-meshheading:10871467-Female,
pubmed-meshheading:10871467-Fetal Membranes, Premature Rupture,
pubmed-meshheading:10871467-Humans,
pubmed-meshheading:10871467-Labor, Obstetric,
pubmed-meshheading:10871467-Matrix Metalloproteinase 2,
pubmed-meshheading:10871467-Obstetric Labor, Premature,
pubmed-meshheading:10871467-Pregnancy,
pubmed-meshheading:10871467-Proto-Oncogene Proteins,
pubmed-meshheading:10871467-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:10871467-Tumor Suppressor Protein p53,
pubmed-meshheading:10871467-bcl-2-Associated X Protein
|
|
pubmed:year |
2000
|
|
pubmed:articleTitle |
Programmed cell death (apoptosis) as a possible pathway to metalloproteinase activation and fetal membrane degradation in premature rupture of membranes.
|
|
pubmed:affiliation |
Maternal-Fetal Group and the Perinatal Research Center of The Women's Health Research and Education Foundation, Nashville, TN 37203, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
