rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5472
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pubmed:dateCreated |
2000-6-29
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pubmed:abstractText |
Wnt-Frizzled (Fz) signaling pathways play recurring important roles during the development and homeostasis of vertebrates and invertebrates. Fz receptors can signal through beta-catenin-dependent and -independent pathways. In Drosophila, Fz and Fz2 are redundant receptors for Wg. In addition, Fz conveys signals through a distinct pathway to organize planar polarization of epithelial structures. We demonstrate that the cytoplasmic sequences of Fz2 and Fz preferentially activate the beta-catenin and planar polarity cascade, respectively. Both receptors activate either pathway, but with different efficiencies. Intrinsic differences in signaling efficiency in closely related receptors might be a general mechanism for generating signaling specificity in vivo.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Armadillo Domain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Frizzled Receptors,
http://linkedlifedata.com/resource/pubmed/chemical/Insect Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, G-Protein-Coupled,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neurotransmitter,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt1 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Xenopus Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Zebrafish Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/armadillo protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin,
http://linkedlifedata.com/resource/pubmed/chemical/beta-catenin protein, Xenopus,
http://linkedlifedata.com/resource/pubmed/chemical/dishevelled proteins,
http://linkedlifedata.com/resource/pubmed/chemical/fz protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/fz2 protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/wg protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
9
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pubmed:volume |
288
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1825-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10846164-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:10846164-Animals,
pubmed-meshheading:10846164-Armadillo Domain Proteins,
pubmed-meshheading:10846164-Body Patterning,
pubmed-meshheading:10846164-Cytoskeletal Proteins,
pubmed-meshheading:10846164-Drosophila,
pubmed-meshheading:10846164-Drosophila Proteins,
pubmed-meshheading:10846164-Eye,
pubmed-meshheading:10846164-Frizzled Receptors,
pubmed-meshheading:10846164-Insect Proteins,
pubmed-meshheading:10846164-Larva,
pubmed-meshheading:10846164-Ligands,
pubmed-meshheading:10846164-Membrane Proteins,
pubmed-meshheading:10846164-Mutation,
pubmed-meshheading:10846164-Phenotype,
pubmed-meshheading:10846164-Phosphoproteins,
pubmed-meshheading:10846164-Photoreceptor Cells, Invertebrate,
pubmed-meshheading:10846164-Protein Structure, Tertiary,
pubmed-meshheading:10846164-Proto-Oncogene Proteins,
pubmed-meshheading:10846164-Receptors, G-Protein-Coupled,
pubmed-meshheading:10846164-Receptors, Neurotransmitter,
pubmed-meshheading:10846164-Recombinant Fusion Proteins,
pubmed-meshheading:10846164-Signal Transduction,
pubmed-meshheading:10846164-Trans-Activators,
pubmed-meshheading:10846164-Transcription Factors,
pubmed-meshheading:10846164-Wing,
pubmed-meshheading:10846164-Wnt Proteins,
pubmed-meshheading:10846164-Wnt1 Protein,
pubmed-meshheading:10846164-Xenopus,
pubmed-meshheading:10846164-Xenopus Proteins,
pubmed-meshheading:10846164-Zebrafish Proteins,
pubmed-meshheading:10846164-beta Catenin
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pubmed:year |
2000
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pubmed:articleTitle |
Signaling specificity by Frizzled receptors in Drosophila.
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pubmed:affiliation |
European Molecular Biology Laboratory, Developmental Biology Programme, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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