Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5472
pubmed:dateCreated
2000-6-29
pubmed:abstractText
Wnt-Frizzled (Fz) signaling pathways play recurring important roles during the development and homeostasis of vertebrates and invertebrates. Fz receptors can signal through beta-catenin-dependent and -independent pathways. In Drosophila, Fz and Fz2 are redundant receptors for Wg. In addition, Fz conveys signals through a distinct pathway to organize planar polarization of epithelial structures. We demonstrate that the cytoplasmic sequences of Fz2 and Fz preferentially activate the beta-catenin and planar polarity cascade, respectively. Both receptors activate either pathway, but with different efficiencies. Intrinsic differences in signaling efficiency in closely related receptors might be a general mechanism for generating signaling specificity in vivo.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing, http://linkedlifedata.com/resource/pubmed/chemical/Armadillo Domain Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Frizzled Receptors, http://linkedlifedata.com/resource/pubmed/chemical/Insect Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Ligands, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, G-Protein-Coupled, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neurotransmitter, http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors, http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Wnt1 Protein, http://linkedlifedata.com/resource/pubmed/chemical/Xenopus Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Zebrafish Proteins, http://linkedlifedata.com/resource/pubmed/chemical/armadillo protein, Drosophila, http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin, http://linkedlifedata.com/resource/pubmed/chemical/beta-catenin protein, Xenopus, http://linkedlifedata.com/resource/pubmed/chemical/dishevelled proteins, http://linkedlifedata.com/resource/pubmed/chemical/fz protein, Drosophila, http://linkedlifedata.com/resource/pubmed/chemical/fz2 protein, Drosophila, http://linkedlifedata.com/resource/pubmed/chemical/wg protein, Drosophila
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0036-8075
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
288
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1825-8
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:10846164-Adaptor Proteins, Signal Transducing, pubmed-meshheading:10846164-Animals, pubmed-meshheading:10846164-Armadillo Domain Proteins, pubmed-meshheading:10846164-Body Patterning, pubmed-meshheading:10846164-Cytoskeletal Proteins, pubmed-meshheading:10846164-Drosophila, pubmed-meshheading:10846164-Drosophila Proteins, pubmed-meshheading:10846164-Eye, pubmed-meshheading:10846164-Frizzled Receptors, pubmed-meshheading:10846164-Insect Proteins, pubmed-meshheading:10846164-Larva, pubmed-meshheading:10846164-Ligands, pubmed-meshheading:10846164-Membrane Proteins, pubmed-meshheading:10846164-Mutation, pubmed-meshheading:10846164-Phenotype, pubmed-meshheading:10846164-Phosphoproteins, pubmed-meshheading:10846164-Photoreceptor Cells, Invertebrate, pubmed-meshheading:10846164-Protein Structure, Tertiary, pubmed-meshheading:10846164-Proto-Oncogene Proteins, pubmed-meshheading:10846164-Receptors, G-Protein-Coupled, pubmed-meshheading:10846164-Receptors, Neurotransmitter, pubmed-meshheading:10846164-Recombinant Fusion Proteins, pubmed-meshheading:10846164-Signal Transduction, pubmed-meshheading:10846164-Trans-Activators, pubmed-meshheading:10846164-Transcription Factors, pubmed-meshheading:10846164-Wing, pubmed-meshheading:10846164-Wnt Proteins, pubmed-meshheading:10846164-Wnt1 Protein, pubmed-meshheading:10846164-Xenopus, pubmed-meshheading:10846164-Xenopus Proteins, pubmed-meshheading:10846164-Zebrafish Proteins, pubmed-meshheading:10846164-beta Catenin
pubmed:year
2000
pubmed:articleTitle
Signaling specificity by Frizzled receptors in Drosophila.
pubmed:affiliation
European Molecular Biology Laboratory, Developmental Biology Programme, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't