Source:http://linkedlifedata.com/resource/pubmed/id/10835489
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0003968,
umls-concept:C0007271,
umls-concept:C0024623,
umls-concept:C0031928,
umls-concept:C0032659,
umls-concept:C0042890,
umls-concept:C0053396,
umls-concept:C0282440,
umls-concept:C0442027,
umls-concept:C0681850,
umls-concept:C0683149,
umls-concept:C1096777,
umls-concept:C1280500,
umls-concept:C1515075,
umls-concept:C1550501,
umls-concept:C1556094,
umls-concept:C1706203,
umls-concept:C2349001,
umls-concept:C2697811
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| pubmed:issue |
5
|
| pubmed:dateCreated |
2000-7-18
|
| pubmed:abstractText |
Prior to a randomized controlled trial to prevent gastric cancer by oral supplementation of beta-carotene and vitamin C in a high-risk Japanese population, we examined the serum response to three-month oral supplementation of beta-carotene (0, 3, 30 mg / day) and vitamin C (0, 50, 1000 mg / day) by a three-by-three factorial design using 54 subjects (age range = 40 - 69 years). Serum concentrations of carotenoids, alpha-tocopherol, and ascorbic acid were examined at baseline, and one, two, and three-month points. Both serum beta-carotene and ascorbic acid were significantly higher in high-dose groups than in each placebo group during the supplementation. The serum beta-carotene increased gradually (597 - 830% increase) during the study, whereas the serum ascorbic acid reached nearly a steady-state at the one-month point and remained stable thereafter (88 - 95% increase). No statistically significant interaction between beta-carotene and vitamin C supplementations was observed either for serum beta-carotene or for serum ascorbic acid. Among carotenoids and alpha-tocopherol examined, serum lycopene in the high-dose beta-carotene group was significantly higher than in the placebo group at all points. No unfavorable change in carotenoids and alpha-tocopherol was observed in any group.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
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| pubmed:issn |
0910-5050
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
91
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
464-70
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10835489-Administration, Oral,
pubmed-meshheading:10835489-Adult,
pubmed-meshheading:10835489-Aged,
pubmed-meshheading:10835489-Analysis of Variance,
pubmed-meshheading:10835489-Ascorbic Acid,
pubmed-meshheading:10835489-Female,
pubmed-meshheading:10835489-Gastritis, Atrophic,
pubmed-meshheading:10835489-Humans,
pubmed-meshheading:10835489-Japan,
pubmed-meshheading:10835489-Male,
pubmed-meshheading:10835489-Middle Aged,
pubmed-meshheading:10835489-Pilot Projects,
pubmed-meshheading:10835489-Regression Analysis,
pubmed-meshheading:10835489-Stomach Neoplasms,
pubmed-meshheading:10835489-Time Factors,
pubmed-meshheading:10835489-Vitamin E,
pubmed-meshheading:10835489-beta Carotene
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Effects of three-month oral supplementation of beta-carotene and vitamin C on serum concentrations of carotenoids and vitamins in middle-aged subjects: a pilot study for a randomized controlled trial to prevent gastric cancer in high-risk Japanese population.
|
| pubmed:affiliation |
Epidemiology and Biostatistics Division, National Cancer Center Research Institute East, 6-5-1 Kashiwanoha, Kashiwa 277-8577, Japan. stssasak@east.ncc.go.jp.
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| pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|