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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0024623,
umls-concept:C0030946,
umls-concept:C0069515,
umls-concept:C0085862,
umls-concept:C0185117,
umls-concept:C0220901,
umls-concept:C0332281,
umls-concept:C1299583,
umls-concept:C1549571,
umls-concept:C1608386,
umls-concept:C1704824,
umls-concept:C2347946,
umls-concept:C2911684
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pubmed:issue |
11
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pubmed:dateCreated |
2000-7-6
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pubmed:abstractText |
The c-erbB-2 gene (encoding the protein p185) is overexpressed in diverse human cancers and has been implicated to be of prognostic value in gastric cancer. Recent studies suggest a role of p185 in tumor progression by specifically promoting the invasive capacity of tumor cells. Therefore, the present study was conducted with the following three objectives: (1) to support the prognostic value of c-erbB-2 in gastric cancer in a large prospective series using a monoclonal antibody and a highly sensitive immunohistochemical method; (2) to determine the association of c-erbB-2 expression with the expression of invasion-related genes; and (3) to perform the first overall multivariate analysis including c-erbB-2 and the invasion-related tumor-associated protease systems.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0732-183X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2201-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10829039-Adult,
pubmed-meshheading:10829039-Aged,
pubmed-meshheading:10829039-Aged, 80 and over,
pubmed-meshheading:10829039-Chi-Square Distribution,
pubmed-meshheading:10829039-Endopeptidases,
pubmed-meshheading:10829039-Female,
pubmed-meshheading:10829039-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:10829039-Genes, erbB-2,
pubmed-meshheading:10829039-Humans,
pubmed-meshheading:10829039-Immunohistochemistry,
pubmed-meshheading:10829039-Male,
pubmed-meshheading:10829039-Middle Aged,
pubmed-meshheading:10829039-Predictive Value of Tests,
pubmed-meshheading:10829039-Prognosis,
pubmed-meshheading:10829039-Proportional Hazards Models,
pubmed-meshheading:10829039-Prospective Studies,
pubmed-meshheading:10829039-Risk Factors,
pubmed-meshheading:10829039-Stomach Neoplasms,
pubmed-meshheading:10829039-Survival Analysis
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pubmed:year |
2000
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pubmed:articleTitle |
c-erbB-2 is of independent prognostic relevance in gastric cancer and is associated with the expression of tumor-associated protease systems.
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pubmed:affiliation |
Department of Surgery, Klinikum Grosshadern, Ludwig Maximilians University of Munich, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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