Linked Life Data

10828475

Source:http://linkedlifedata.com/resource/pubmed/id/10828475

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2000-8-30
pubmed:abstractText
Colonic ischaemia may complicate aortic graft surgery with high mortality from associated colonic necrosis. Loss of the mucosal barrier function due to ischaemia may promote translocation of endotoxins with secondary systemic disseminated coagulation leading to multiple organ failure. Short-chain fatty acids (SCFAs) stimulate the microcirculation in the human rectum. The aim of this study was to investigate whether SCFA enemas influence systemic endotoxinaemia and fibrinolytic activity during and after elective aortic graft surgery for arteriosclerosis. Thirty-two patients were randomized to SCFA or placebo enemas twice daily from the day before surgery to 7 days after. Blood samples for endotoxin, plasminogen activator inhibitor-1 (PAI-1) activity, tissue-type plasminogen activator (t-PA) antigen, and cross-linked fibrin degradation products (XL-FDP) were drawn before, during, and 7 days after surgery. Four patients, two in each treatment group, developed postoperative endotoxinaemia. PAI-1 was significantly higher on days 2 and 4 in SCFA-treated patients, whereas t-PA was comparable Petween the groups. During the postoperative course, a progressive and near-identical XL-FDP increase was found in the two groups. In elective aortic graft surgery for arteriosclerosis, SCFA enemas likely stimulate systemic PAI-1 activity by promoting colonic tissue reperfusion following aortic unclamping. Endotoxinaemia and fibrinolytic shutdown are uncommon findings.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0049-3848
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
98
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
361-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:10828475-Aged, pubmed-meshheading:10828475-Anti-Bacterial Agents, pubmed-meshheading:10828475-Antigens, pubmed-meshheading:10828475-Aorta, Abdominal, pubmed-meshheading:10828475-Arteriosclerosis, pubmed-meshheading:10828475-Blood Vessel Prosthesis, pubmed-meshheading:10828475-Colitis, Ischemic, pubmed-meshheading:10828475-Colon, pubmed-meshheading:10828475-Double-Blind Method, pubmed-meshheading:10828475-Endotoxemia, pubmed-meshheading:10828475-Enema, pubmed-meshheading:10828475-Fatty Acids, Volatile, pubmed-meshheading:10828475-Female, pubmed-meshheading:10828475-Fibrin Fibrinogen Degradation Products, pubmed-meshheading:10828475-Fibrinolysis, pubmed-meshheading:10828475-Humans, pubmed-meshheading:10828475-Male, pubmed-meshheading:10828475-Middle Aged, pubmed-meshheading:10828475-Placebos, pubmed-meshheading:10828475-Plasminogen Activator Inhibitor 1, pubmed-meshheading:10828475-Thromboembolism, pubmed-meshheading:10828475-Time Factors, pubmed-meshheading:10828475-Tissue Plasminogen Activator, pubmed-meshheading:10828475-Wound Infection
pubmed:year
2000
pubmed:articleTitle
Short-chain fatty acid enemas stimulate plasminogen activator inhibitor-1 after abdominal aortic graft surgery: a double-blinded, placebo-controlled study.
pubmed:affiliation
Department of Surgical Gastroenterology L, Aarhus University Hospital, Denmark. f.v.mortensen@dadlnet.dk
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U.S. Gov't