Linked Life Data

10826514

Source:http://linkedlifedata.com/resource/pubmed/id/10826514

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2000-8-10
pubmed:abstractText
Beta-3-adrenergic receptor (beta-3-AR) and insulin receptor substrate 1 (IRS-1) have been implicated in the pathogenesis of obesity and in obesity related increase in insulin resistance which is associated with, among other diseases, dyslipidemia and type 2 diabetes mellitus. We studied 210 white female Caucasian obese subjects, who underwent a formal weight loss program (Optifast). We examined the association between mutations of the IRS-1 gene at codon 972, mutations of the beta-3-AR gene at codon 64, and the combination of both mutations with the degree of weight loss, waist to hip ratio and the prevalence of hypertension, dyslipidemia and type 2 diabetes mellitus. Twenty-four women (11.4%) were polymorph only for the beta-3-AR mutation, 23 women (10.9%) only for the IRS-1 mutation, and 6 subjects (2.9%) were polymorph for both alleles. No patient displayed a homozygous polymorphism. Similar frequencies of these polymorphisms were observed when the 100 non-obese control women were tested (14.0, 15.0, 3.0, respectively). After 13 weeks of weight loss the group with multiple polymorph alleles had lost less of their weight than the obese controls without mutation (Delta BMI 5.32+/-0.18 versus 6.12+/-0.2 kg/m2, p<0.05). In this group, the frequency of type 2 diabetes (66.7%) was significantly higher than in the obese control group without mutations (16.7%, p=0.008). Our findings suggest there is a synergy between the polymorphisms of Trp64Arg beta-3-AR and Gly972Arg IRS-1 in Caucasian German obese women leading to a decreased weight loss. This seems to be accompanied with an increased frequency of type 2 diabetes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0947-7349
pubmed:author
pubmed:issnType
Print
pubmed:volume
108
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
86-92
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:10826514-Adult, pubmed-meshheading:10826514-Body Constitution, pubmed-meshheading:10826514-Cardiovascular Diseases, pubmed-meshheading:10826514-Cholesterol, pubmed-meshheading:10826514-Diabetes Mellitus, Type 2, pubmed-meshheading:10826514-Female, pubmed-meshheading:10826514-Humans, pubmed-meshheading:10826514-Hypertension, pubmed-meshheading:10826514-Insulin Receptor Substrate Proteins, pubmed-meshheading:10826514-Insulin Resistance, pubmed-meshheading:10826514-Middle Aged, pubmed-meshheading:10826514-Mutation, pubmed-meshheading:10826514-Obesity, pubmed-meshheading:10826514-Phosphoproteins, pubmed-meshheading:10826514-Receptors, Adrenergic, beta, pubmed-meshheading:10826514-Risk Factors, pubmed-meshheading:10826514-Triglycerides, pubmed-meshheading:10826514-Weight Loss
pubmed:year
2000
pubmed:articleTitle
A study on the genetics of obesity: influence of polymorphisms of the beta-3-adrenergic receptor and insulin receptor substrate 1 in relation to weight loss, waist to hip ratio and frequencies of common cardiovascular risk factors.
pubmed:affiliation
Abt. Klinische Endokrinologie, Zentrum Innere Medizin und Dermatologie, Medizinische Hochschule Hannover, Germany.
pubmed:publicationType
Journal Article