Linked Life Data

10826005

Source:http://linkedlifedata.com/resource/pubmed/id/10826005

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2000-6-8
pubmed:abstractText
Previous clinical and experimental investigations have suggested that pentoxifylline, a methylxanthine, can improve cerebrovascular circulation and reduce cerebral edema in cerebrovascular disorders. Pentoxifylline's mechanism of action includes such rheologic effects as enhanced red cell deformability, alterations in leukocyte activation, and modification of coagulation parameters. The purpose of our investigation was to determine the effects of pentoxifylline in an experimental spinal cord injury model. A compression device was used to cause a reproducible spinal cord injury in adult female albino rats. Spinal cord blood flow was monitored using a laser Doppler flow meter pre- and postinjury for 4 hours. The experimental group (N = 7) was injected with pentoxifylline 10 minutes prior to injury. The control group (N = 5) received an identical protocol, except that this group was injected with an equal amount of saline. Results of this investigation revealed that pentoxifylline treatment significantly increased spinal cord blood flow. In the pentoxifylline-treated group, spinal cord blood flow was significantly higher from 120 to 240 minutes postinjury compared with that of the control group. We conclude that via its multiple physiologic effects, pentoxifylline significantly improves spinal cord blood flow in experimental spinal cord injury.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1048-9886
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
23-6
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
The effects of pentoxifylline on spinal cord blood flow after experimental spinal cord injury.
pubmed:affiliation
Department of Neurosurgery, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
pubmed:publicationType
Journal Article