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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
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pubmed:dateCreated |
2000-8-2
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pubmed:abstractText |
To determine the effect of interleukin 4 (IL-4) administration in a live sepsis model characterised by high-level production of tumour necrosis factor a (TNF-alpha), mice infected systemically with lethal or sublethal inocula of Pseudomonas aeruginosa were given the recombinant cytokine at different times before infection. Improved survival and decreased TNF-alpha production were observed in lethally infected mice treated with the cytokine 1 day before challenge. In contrast, increased mortality and overproduction of TNF-alpha were observed in sublethally infected mice given IL-4 at the time of infection.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Apr
|
|
pubmed:issn |
1043-4666
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:volume |
12
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
417-21
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|
pubmed:dateRevised |
2004-11-17
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|
pubmed:meshHeading |
pubmed-meshheading:10805227-Animals,
pubmed-meshheading:10805227-Cells, Cultured,
pubmed-meshheading:10805227-Disease Models, Animal,
pubmed-meshheading:10805227-Interleukin-12,
pubmed-meshheading:10805227-Interleukin-4,
pubmed-meshheading:10805227-Lipopolysaccharides,
pubmed-meshheading:10805227-Macrophages,
pubmed-meshheading:10805227-Mice,
pubmed-meshheading:10805227-Pseudomonas Infections,
pubmed-meshheading:10805227-Pseudomonas aeruginosa,
pubmed-meshheading:10805227-Recombinant Proteins,
pubmed-meshheading:10805227-Sepsis,
pubmed-meshheading:10805227-Tumor Necrosis Factor-alpha
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|
pubmed:year |
2000
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|
pubmed:articleTitle |
Dual effect of IL-4 on resistance to systemic gram-negative infection and production of TNF-alpha.
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|
pubmed:affiliation |
Department of Experimental Medicine, University of Perugia, Italy.
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pubmed:publicationType |
Journal Article
|
