| pubmed-article:10785439 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10785439 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:10785439 | lifeskim:mentions | umls-concept:C0291573 | lld:lifeskim |
| pubmed-article:10785439 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:10785439 | lifeskim:mentions | umls-concept:C0004112 | lld:lifeskim |
| pubmed-article:10785439 | lifeskim:mentions | umls-concept:C0338451 | lld:lifeskim |
| pubmed-article:10785439 | lifeskim:mentions | umls-concept:C0012860 | lld:lifeskim |
| pubmed-article:10785439 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10785439 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:10785439 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:10785439 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:10785439 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:10785439 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10785439 | pubmed:dateCreated | 2000-6-13 | lld:pubmed |
| pubmed-article:10785439 | pubmed:abstractText | Frontotemporal dementia (FTD) is a neurodegenerative disease which affects mainly the frontal and anterior temporal cortex. It is associated with neuronal loss, gliosis, and microvacuolation of lamina I to III in these brain regions. In previous studies we have described neurons with DNA damage in the absence of tangle formation and suggested this may result in tangle-independent mechanisms of neurodegeneration in the AD brain. In the present study, we sought to examine DNA fragmentation and activated caspase-3 expression in FTD brain where tangle formation is largely absent. The results demonstrate that numerous nuclei were TdT positive in all FTD brains examined. Activated caspase-3 immunoreactivity was detected in both neurons and astrocytes and was elevated in FTD cases as compared to control cases. A subset of activated caspase-3-positive cells were also TdT positive. In addition, the cell bodies of a subset of astrocytes showed enlarged, irregular shapes, and vacuolation and their processes appeared fragmented. These degenerating astrocytes were positive for activated caspase-3 and colocalized with robust TdT-labeled nuclei. These findings suggest that a subset of astrocytes exhibit degeneration and that DNA damage and activated caspase-3 may contribute to neuronal cell death and astrocyte degeneration in the FTD brain. Our results suggest that apoptosis may be a mechanism of neuronal cell death in FTD as well as in AD (228). | lld:pubmed |
| pubmed-article:10785439 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10785439 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10785439 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10785439 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10785439 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10785439 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10785439 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10785439 | pubmed:month | May | lld:pubmed |
| pubmed-article:10785439 | pubmed:issn | 0014-4886 | lld:pubmed |
| pubmed-article:10785439 | pubmed:author | pubmed-author:CotmanC WCW | lld:pubmed |
| pubmed-article:10785439 | pubmed:author | pubmed-author:ChubbCC | lld:pubmed |
| pubmed-article:10785439 | pubmed:author | pubmed-author:MillerB LBL | lld:pubmed |
| pubmed-article:10785439 | pubmed:author | pubmed-author:GEEWW | lld:pubmed |
| pubmed-article:10785439 | pubmed:author | pubmed-author:KimR CRC | lld:pubmed |
| pubmed-article:10785439 | pubmed:author | pubmed-author:SherWW | lld:pubmed |
| pubmed-article:10785439 | pubmed:author | pubmed-author:TomaselliK... | lld:pubmed |
| pubmed-article:10785439 | pubmed:author | pubmed-author:NicholK EKE | lld:pubmed |
| pubmed-article:10785439 | pubmed:author | pubmed-author:SitchTT | lld:pubmed |
| pubmed-article:10785439 | pubmed:copyrightInfo | Copyright 2000 Academic Press. | lld:pubmed |
| pubmed-article:10785439 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10785439 | pubmed:volume | 163 | lld:pubmed |
| pubmed-article:10785439 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10785439 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10785439 | pubmed:pagination | 9-19 | lld:pubmed |
| pubmed-article:10785439 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10785439 | pubmed:meshHeading | pubmed-meshheading:10785439... | lld:pubmed |
| pubmed-article:10785439 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10785439 | pubmed:articleTitle | DNA damage and activated caspase-3 expression in neurons and astrocytes: evidence for apoptosis in frontotemporal dementia. | lld:pubmed |
| pubmed-article:10785439 | pubmed:affiliation | Institute for Brain Aging and Dementia, University of California, Irvine, Irvine, California 92697, USA. | lld:pubmed |
| pubmed-article:10785439 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10785439 | pubmed:publicationType | Case Reports | lld:pubmed |
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