Source:http://linkedlifedata.com/resource/pubmed/id/10785439
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2000-6-13
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| pubmed:abstractText |
Frontotemporal dementia (FTD) is a neurodegenerative disease which affects mainly the frontal and anterior temporal cortex. It is associated with neuronal loss, gliosis, and microvacuolation of lamina I to III in these brain regions. In previous studies we have described neurons with DNA damage in the absence of tangle formation and suggested this may result in tangle-independent mechanisms of neurodegeneration in the AD brain. In the present study, we sought to examine DNA fragmentation and activated caspase-3 expression in FTD brain where tangle formation is largely absent. The results demonstrate that numerous nuclei were TdT positive in all FTD brains examined. Activated caspase-3 immunoreactivity was detected in both neurons and astrocytes and was elevated in FTD cases as compared to control cases. A subset of activated caspase-3-positive cells were also TdT positive. In addition, the cell bodies of a subset of astrocytes showed enlarged, irregular shapes, and vacuolation and their processes appeared fragmented. These degenerating astrocytes were positive for activated caspase-3 and colocalized with robust TdT-labeled nuclei. These findings suggest that a subset of astrocytes exhibit degeneration and that DNA damage and activated caspase-3 may contribute to neuronal cell death and astrocyte degeneration in the FTD brain. Our results suggest that apoptosis may be a mechanism of neuronal cell death in FTD as well as in AD (228).
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
0014-4886
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2000 Academic Press.
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| pubmed:issnType |
Print
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| pubmed:volume |
163
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
9-19
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10785439-Aged,
pubmed-meshheading:10785439-Aged, 80 and over,
pubmed-meshheading:10785439-Apoptosis,
pubmed-meshheading:10785439-Astrocytes,
pubmed-meshheading:10785439-Behavioral Symptoms,
pubmed-meshheading:10785439-Brain,
pubmed-meshheading:10785439-Caspase 3,
pubmed-meshheading:10785439-Caspases,
pubmed-meshheading:10785439-Cell Nucleus,
pubmed-meshheading:10785439-DNA Damage,
pubmed-meshheading:10785439-DNA Fragmentation,
pubmed-meshheading:10785439-Dementia,
pubmed-meshheading:10785439-Fatal Outcome,
pubmed-meshheading:10785439-Female,
pubmed-meshheading:10785439-Frontal Lobe,
pubmed-meshheading:10785439-Glial Fibrillary Acidic Protein,
pubmed-meshheading:10785439-Gliosis,
pubmed-meshheading:10785439-Humans,
pubmed-meshheading:10785439-Male,
pubmed-meshheading:10785439-Middle Aged,
pubmed-meshheading:10785439-Neurites,
pubmed-meshheading:10785439-Neurons,
pubmed-meshheading:10785439-Pyramidal Cells,
pubmed-meshheading:10785439-Temporal Lobe
|
| pubmed:year |
2000
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| pubmed:articleTitle |
DNA damage and activated caspase-3 expression in neurons and astrocytes: evidence for apoptosis in frontotemporal dementia.
|
| pubmed:affiliation |
Institute for Brain Aging and Dementia, University of California, Irvine, Irvine, California 92697, USA.
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| pubmed:publicationType |
Journal Article,
Case Reports
|