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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2000-5-31
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pubmed:abstractText |
Caenorhabditis elegans sur-8 encodes a positive regulator of Ras signaling. We investigated the mechanism by which the human Sur-8 homolog can positively regulate Ras-MAP kinase signaling in mammalian cells. Sur-8 expression enhances Ras- or EGF-induced Raf and ERK activation but has no effect on ERK activation induced by active Raf or MEK. Furthermore, Sur-8 expression does not increase AKT or JNK activation. Sur-8 interacts with Ras and Raf and is able to form a ternary complex with the two proteins. Thus, Sur-8 may function as a scaffold that enhances Ras-MAP kinase signal transduction by facilitating the interaction between Ras and Raf.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10783161-10521400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10783161-10576742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10783161-1322500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10783161-1330321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10783161-1852137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10783161-2247439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10783161-2405488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10783161-2934138,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10783161-7587064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10783161-7888178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10783161-8052307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10783161-8052857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10783161-8131746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10783161-8137421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10783161-8177321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10783161-8264799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10783161-8321321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10783161-8334704,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10783161-8521513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10783161-8521514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10783161-8524119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10783161-8621061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10783161-8621729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10783161-8631302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10783161-9024640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10783161-9069255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10783161-9069260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10783161-9301337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10783161-9618511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10783161-9674433,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10783161-9685325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10783161-9823899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10783161-9825675
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AKT1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Caenorhabditis elegans Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Transferase,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-raf,
http://linkedlifedata.com/resource/pubmed/chemical/SUR-8 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/ras Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0890-9369
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
895-900
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10783161-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:10783161-Blotting, Western,
pubmed-meshheading:10783161-Caenorhabditis elegans Proteins,
pubmed-meshheading:10783161-Carrier Proteins,
pubmed-meshheading:10783161-Cell Line,
pubmed-meshheading:10783161-DNA, Complementary,
pubmed-meshheading:10783161-Dose-Response Relationship, Drug,
pubmed-meshheading:10783161-Enzyme Activation,
pubmed-meshheading:10783161-Epidermal Growth Factor,
pubmed-meshheading:10783161-Glutathione Transferase,
pubmed-meshheading:10783161-Humans,
pubmed-meshheading:10783161-MAP Kinase Signaling System,
pubmed-meshheading:10783161-Plasmids,
pubmed-meshheading:10783161-Precipitin Tests,
pubmed-meshheading:10783161-Protein Binding,
pubmed-meshheading:10783161-Protein-Serine-Threonine Kinases,
pubmed-meshheading:10783161-Proto-Oncogene Proteins,
pubmed-meshheading:10783161-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:10783161-Proto-Oncogene Proteins c-raf,
pubmed-meshheading:10783161-Signal Transduction,
pubmed-meshheading:10783161-Transfection,
pubmed-meshheading:10783161-Two-Hybrid System Techniques,
pubmed-meshheading:10783161-Up-Regulation,
pubmed-meshheading:10783161-ras Proteins
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pubmed:year |
2000
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pubmed:articleTitle |
The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf.
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pubmed:affiliation |
Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109 USA.
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