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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2000-6-13
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pubmed:abstractText |
A contig was constructed centered on the PML (promyelocytic leukemia) gene. Using an exon-trapping approach to identify potential genes from a pool of cosmids located 5' of the PML gene, four exons were identified that showed 100% sequence homology with the previously cloned lysyl oxidase-like (LOXL1) gene. An exon probe identified a single transcript of 2.4 kb on a multitissue Northern blot with a pattern identical to the one reported for the LOXL1 gene. Pulsed-field gel electrophoresis showed comigrating bands for both the PML cDNA and LOXL1 probes, demonstrating a physical linkage between these two genes. These data provide physical mapping information to complement the previous cytogenetic localization of LOXL1.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0301-0171
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2000 S. Karger AG, Basel
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pubmed:issnType |
Print
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
22-4
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:10773658-Blotting, Southern,
pubmed-meshheading:10773658-Chromosomes, Human, Pair 15,
pubmed-meshheading:10773658-Cloning, Molecular,
pubmed-meshheading:10773658-Contig Mapping,
pubmed-meshheading:10773658-Electrophoresis, Gel, Pulsed-Field,
pubmed-meshheading:10773658-Exons,
pubmed-meshheading:10773658-Genetic Linkage,
pubmed-meshheading:10773658-Humans,
pubmed-meshheading:10773658-Neoplasm Proteins,
pubmed-meshheading:10773658-Nuclear Proteins,
pubmed-meshheading:10773658-Polymorphism, Genetic,
pubmed-meshheading:10773658-Protein-Lysine 6-Oxidase,
pubmed-meshheading:10773658-RNA, Messenger,
pubmed-meshheading:10773658-Sequence Homology, Nucleic Acid,
pubmed-meshheading:10773658-Transcription Factors,
pubmed-meshheading:10773658-Tumor Suppressor Proteins
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pubmed:year |
2000
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pubmed:articleTitle |
Physical linkage of the lysyl oxidase-like (LOXL1) gene to the PML gene on human chromosome 15q22.
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pubmed:affiliation |
Molecular Biology Program of Sloan-Kettering Institute and Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
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pubmed:publicationType |
Journal Article
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