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pubmed-article:10765503pubmed:abstractTextCationic lipids are the most widely used nonviral vectors for gene delivery. Upon complexation to DNA, they offer a nonimmunogenic alternative to viral gene transfer. Unfortunately, their in vivo application has been limited due to a serum-associated inhibition of transfection. As a result, significant research effort has focused on overcoming this deleterious effect of serum.lld:pubmed
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pubmed-article:10765503pubmed:articleTitleFormulations which increase the size of lipoplexes prevent serum-associated inhibition of transfection.lld:pubmed
pubmed-article:10765503pubmed:affiliationUMR7001, Vectorologie Moléculaire et Cellulaire, Ecole Nationale Supérieure de Chimie de Paris, France.lld:pubmed
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