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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2000-6-20
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pubmed:abstractText |
Cationic lipids are the most widely used nonviral vectors for gene delivery. Upon complexation to DNA, they offer a nonimmunogenic alternative to viral gene transfer. Unfortunately, their in vivo application has been limited due to a serum-associated inhibition of transfection. As a result, significant research effort has focused on overcoming this deleterious effect of serum.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1099-498X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
32-40
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10765503-3T3 Cells,
pubmed-meshheading:10765503-Acylation,
pubmed-meshheading:10765503-Animals,
pubmed-meshheading:10765503-Cations,
pubmed-meshheading:10765503-Cell Line,
pubmed-meshheading:10765503-DNA,
pubmed-meshheading:10765503-Fluorescence,
pubmed-meshheading:10765503-Genes, Reporter,
pubmed-meshheading:10765503-Genetic Vectors,
pubmed-meshheading:10765503-HeLa Cells,
pubmed-meshheading:10765503-Humans,
pubmed-meshheading:10765503-Hydrogen-Ion Concentration,
pubmed-meshheading:10765503-Light,
pubmed-meshheading:10765503-Lipids,
pubmed-meshheading:10765503-Luciferases,
pubmed-meshheading:10765503-Mice,
pubmed-meshheading:10765503-Plasmids,
pubmed-meshheading:10765503-Scattering, Radiation,
pubmed-meshheading:10765503-Sodium Chloride,
pubmed-meshheading:10765503-Transfection
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pubmed:articleTitle |
Formulations which increase the size of lipoplexes prevent serum-associated inhibition of transfection.
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pubmed:affiliation |
UMR7001, Vectorologie Moléculaire et Cellulaire, Ecole Nationale Supérieure de Chimie de Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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