Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2000-7-13
pubmed:databankReference
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF204277, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF204278, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF204279, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF204280, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF204281, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF204282, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF204283, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF204284, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF204285, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF204286, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF204287, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF204288, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF204289, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF204290
pubmed:abstractText
NF-kappaB and IkappaB proteins have central roles in regulation of inflammation and innate immunity in mammals. Homologues of these proteins also play an important role in regulation of the Drosophila immune response. Here we present a molecular population genetic analysis of Relish, a Drosophila NF-kappaB/IkappaB protein, in Drosophila simulans and D. melanogaster. We find strong evidence for adaptive protein evolution in D. simulans, but not in D. melanogaster. The adaptive evolution appears to be restricted to the IkappaB domain. A possible explanation for these results is that Relish is a site of evolutionary conflict between flies and their microbial pathogens.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10757765-10089204, http://linkedlifedata.com/resource/pubmed/commentcorrection/10757765-1145509, http://linkedlifedata.com/resource/pubmed/commentcorrection/10757765-1283347, http://linkedlifedata.com/resource/pubmed/commentcorrection/10757765-1339305, http://linkedlifedata.com/resource/pubmed/commentcorrection/10757765-1560824, http://linkedlifedata.com/resource/pubmed/commentcorrection/10757765-1904993, http://linkedlifedata.com/resource/pubmed/commentcorrection/10757765-2104802, http://linkedlifedata.com/resource/pubmed/commentcorrection/10757765-2513255, http://linkedlifedata.com/resource/pubmed/commentcorrection/10757765-2612899, http://linkedlifedata.com/resource/pubmed/commentcorrection/10757765-3110004, http://linkedlifedata.com/resource/pubmed/commentcorrection/10757765-7672574, http://linkedlifedata.com/resource/pubmed/commentcorrection/10757765-8277853, http://linkedlifedata.com/resource/pubmed/commentcorrection/10757765-8375663, http://linkedlifedata.com/resource/pubmed/commentcorrection/10757765-8583899, http://linkedlifedata.com/resource/pubmed/commentcorrection/10757765-8816802, http://linkedlifedata.com/resource/pubmed/commentcorrection/10757765-8913769, http://linkedlifedata.com/resource/pubmed/commentcorrection/10757765-9055092, http://linkedlifedata.com/resource/pubmed/commentcorrection/10757765-9443887, http://linkedlifedata.com/resource/pubmed/commentcorrection/10757765-9553148, http://linkedlifedata.com/resource/pubmed/commentcorrection/10757765-9597130, http://linkedlifedata.com/resource/pubmed/commentcorrection/10757765-9611206, http://linkedlifedata.com/resource/pubmed/commentcorrection/10757765-9618447, http://linkedlifedata.com/resource/pubmed/commentcorrection/10757765-9718731, http://linkedlifedata.com/resource/pubmed/commentcorrection/10757765-9725836, http://linkedlifedata.com/resource/pubmed/commentcorrection/10757765-9865689, http://linkedlifedata.com/resource/pubmed/commentcorrection/10757765-9865693, http://linkedlifedata.com/resource/pubmed/commentcorrection/10757765-9865694, http://linkedlifedata.com/resource/pubmed/commentcorrection/10757765-9872962
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0016-6731
pubmed:author
pubmed:issnType
Print
pubmed:volume
154
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1231-8
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Adaptive evolution of relish, a Drosophila NF-kappaB/IkappaB protein.
pubmed:affiliation
Section of Integrative Biology and Institute for Cellular and Molecular Biology, University of Texas, Austin, Texas 78712, USA. djbegun@mail.utexas.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.