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pubmed-article:10753746pubmed:abstractTextIn the fruit fly Drosophila, the Inscuteable protein localises to the apical cell cortex in neuroblasts and directs both the apical-basal orientation of the mitotic spindle and the basal localisation of the protein determinants Numb and Prospero during mitosis. Asymmetric localisation of Inscuteable is initiated during neuroblast delamination by direct binding to Bazooka, an apically localised protein that contains protein-interaction motifs known as PDZ domains. How apically localised Inscuteable directs asymmetric cell divisions is unclear.lld:pubmed
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pubmed-article:10753746pubmed:articleTitleA protein complex containing Inscuteable and the Galpha-binding protein Pins orients asymmetric cell divisions in Drosophila.lld:pubmed
pubmed-article:10753746pubmed:affiliationResearch Institute of Molecular Pathology (IMP), Vienna, A-1030, Austria.lld:pubmed
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