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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2000-5-16
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pubmed:databankReference |
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pubmed:abstractText |
In the fruit fly Drosophila, the Inscuteable protein localises to the apical cell cortex in neuroblasts and directs both the apical-basal orientation of the mitotic spindle and the basal localisation of the protein determinants Numb and Prospero during mitosis. Asymmetric localisation of Inscuteable is initiated during neuroblast delamination by direct binding to Bazooka, an apically localised protein that contains protein-interaction motifs known as PDZ domains. How apically localised Inscuteable directs asymmetric cell divisions is unclear.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Heterotrimeric GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Insect Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Rapsynoid protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/bazooka protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/insc protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0960-9822
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
353-62
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10753746-Amino Acid Sequence,
pubmed-meshheading:10753746-Animals,
pubmed-meshheading:10753746-Biological Transport,
pubmed-meshheading:10753746-Carrier Proteins,
pubmed-meshheading:10753746-Cell Cycle Proteins,
pubmed-meshheading:10753746-Cell Division,
pubmed-meshheading:10753746-Cell Polarity,
pubmed-meshheading:10753746-Cytoskeletal Proteins,
pubmed-meshheading:10753746-Drosophila,
pubmed-meshheading:10753746-Drosophila Proteins,
pubmed-meshheading:10753746-Epithelial Cells,
pubmed-meshheading:10753746-Heterotrimeric GTP-Binding Proteins,
pubmed-meshheading:10753746-Insect Proteins,
pubmed-meshheading:10753746-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:10753746-Models, Biological,
pubmed-meshheading:10753746-Molecular Sequence Data,
pubmed-meshheading:10753746-Nerve Tissue,
pubmed-meshheading:10753746-Neuropeptides,
pubmed-meshheading:10753746-Signal Transduction,
pubmed-meshheading:10753746-Stem Cells
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pubmed:year |
2000
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pubmed:articleTitle |
A protein complex containing Inscuteable and the Galpha-binding protein Pins orients asymmetric cell divisions in Drosophila.
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pubmed:affiliation |
Research Institute of Molecular Pathology (IMP), Vienna, A-1030, Austria.
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pubmed:publicationType |
Journal Article,
Comparative Study
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