Source:http://linkedlifedata.com/resource/pubmed/id/10753039
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2000-5-2
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pubmed:abstractText |
Tumour necrosis factor-alpha (TNF-alpha) is believed to influence skeletal muscle insulin resistance. Two G --> A transitions in the promoter region of TNF-alpha at position -238 and -308 have been identified that could play a part in transcriptional regulation of the gene. Insulin resistance is an independent familial trait that predicts the development of Type II (non-insulin-dependent) diabetes mellitus. We investigated the influence on insulin sensitivity and insulin secretion of both polymorphisms in a cohort of young healthy relatives of patients with Type II diabetes.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0012-186X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
181-4
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:10753039-Adult,
pubmed-meshheading:10753039-Blood Glucose,
pubmed-meshheading:10753039-Diabetes Mellitus, Type 2,
pubmed-meshheading:10753039-Female,
pubmed-meshheading:10753039-Genotype,
pubmed-meshheading:10753039-Glucose Clamp Technique,
pubmed-meshheading:10753039-Heterozygote,
pubmed-meshheading:10753039-Homozygote,
pubmed-meshheading:10753039-Humans,
pubmed-meshheading:10753039-Insulin,
pubmed-meshheading:10753039-Male,
pubmed-meshheading:10753039-Middle Aged,
pubmed-meshheading:10753039-Point Mutation,
pubmed-meshheading:10753039-Polymorphism, Genetic,
pubmed-meshheading:10753039-Promoter Regions, Genetic,
pubmed-meshheading:10753039-Tumor Necrosis Factor-alpha
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pubmed:year |
2000
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pubmed:articleTitle |
The tumour necrosis factor alpha -238 G --> A and -308 G --> A promoter polymorphisms are not associated with insulin sensitivity and insulin secretion in young healthy relatives of Type II diabetic patients.
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pubmed:affiliation |
Medical Clinic of the University of Tübingen, Section IV, Internal Medicine and Endocrinology, Germany.
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pubmed:publicationType |
Journal Article
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