|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2000-4-4
|
|
pubmed:abstractText |
Myelin protein reactive CD4+ T cells are considered to be involved in the proposed immunopathogenesis of multiple sclerosis (MS). One particularly important molecule for T-cell activation is the CD40L (gp39) that is expressed on the surface of T cells. This study focuses on the CD40 and the CD40L expression on mononuclear cells prepared from blood from patients with MS, other neurological diseases (OND) and healthy subjects. Immunostaining followed by a three channel flow cytometry was adopted. Patients with MS had higher levels of CD3+CD40L+, CD4+CD40L+ and CD8+CD40L+ T cells compared to patients with OND and healthy subjects. Cross-sectional comparisons revealed that the elevation of CD40L+ T cell subtypes was confined to the patients with untreated MS and not observed in the patients with MS treated with interferon-beta (IFN-beta). Follow up studies showed that levels of CD3+CD40L+ and CD4+CD40L+ T cells decreased in individual patients after the initiation of the IFN-beta treatment. The enhanced expression of CD40L on CD3+, CD4+ and CD8+ T cells in patients with MS may implicate a role for this molecule in disease immunopathogenesis.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD14,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD20,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD40,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/CD40 Ligand,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-beta,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/interferon beta 1a,
http://linkedlifedata.com/resource/pubmed/chemical/interferon beta-1b
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0300-9475
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
51
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
312-20
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:10736102-Adult,
pubmed-meshheading:10736102-Antigens, CD14,
pubmed-meshheading:10736102-Antigens, CD20,
pubmed-meshheading:10736102-Antigens, CD3,
pubmed-meshheading:10736102-Antigens, CD4,
pubmed-meshheading:10736102-Antigens, CD40,
pubmed-meshheading:10736102-Antigens, CD8,
pubmed-meshheading:10736102-CD4-CD8 Ratio,
pubmed-meshheading:10736102-CD40 Ligand,
pubmed-meshheading:10736102-Female,
pubmed-meshheading:10736102-Flow Cytometry,
pubmed-meshheading:10736102-Humans,
pubmed-meshheading:10736102-Immunophenotyping,
pubmed-meshheading:10736102-Interferon-beta,
pubmed-meshheading:10736102-Ligands,
pubmed-meshheading:10736102-Male,
pubmed-meshheading:10736102-Membrane Glycoproteins,
pubmed-meshheading:10736102-Middle Aged,
pubmed-meshheading:10736102-Multiple Sclerosis,
pubmed-meshheading:10736102-Nervous System Diseases,
pubmed-meshheading:10736102-Recombinant Proteins,
pubmed-meshheading:10736102-T-Lymphocyte Subsets
|
|
pubmed:year |
2000
|
|
pubmed:articleTitle |
Elevated CD40 ligand expressing blood T-cell levels in multiple sclerosis are reversed by interferon-beta treatment.
|
|
pubmed:affiliation |
Division of Neurology, Neuroimmunology Unit, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
