Source:http://linkedlifedata.com/resource/pubmed/id/10730759
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2000-4-27
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| pubmed:abstractText |
To investigate morphological changes occurring during cutaneous photoageing, a correlation between the number of infiltrating cells in the dermis and the degree of collagen damage was examined using sections from clinically normal chronically sun-exposed and sun-protected skin of Japanese female subjects. Haematoxylin and eosin-stained sections from 134 sun-exposed (subjects aged 3-82 years) and 73 sun-protected (subjects aged 1-86 years) areas demonstrated a predominant lymphoid cell and to a lesser extent histiocyte infiltration. The mean +/- SD number of lymphoid cells and histiocytes in the sun-exposed skin sections (427.0+/-192.2 and 147.8+/-83.3 cells/mm2, respectively) was significantly higher than in the sun-protected skin sections (292.6+/-98.3 and 125.9+/-59.0 cells/mm2, respectively) (P < 0.001 and P < 0.05, respectively), and the number of lymphoid cells in the sun-exposed skin sections increased significantly with age up to 50 years (r = 0.400, P < 0.001). Sun-exposed skin sections with severe collagen degeneration had a significantly higher number of lymphoid cells than those with slightly degenerated collagen (mean 626.3 vs. 482.4 cells/mm2, P < 0.01). The mean count of mast cells in sun-exposed skin was 202.0 cells/mm2; this did not vary with the age of the subjects or the level of collagen damage. Immunohistochemical studies using 24 frozen sections identified most of the lymphoid cells infiltrating sun-exposed skin as memory T lymphocytes (CD3+, CD4+ and CD45RO+). The number of cells which displayed immunoreactivity to matrix metalloproteinase (MMP)-1 in the sun-exposed skin sections was significantly higher than in the sun-protected skin sections (mean 170.2 vs. 113.6 cells/mm2, P < 0.05). Among these cells were observed CD3 and MMP-1 double-stained T lymphocytes, and T lymphocytes contacting MMP-1-positive cells. These morphological observations suggest that T lymphocytes infiltrating photodamaged skin may play a part in the degeneration and reduction of collagen through MMP-1 activity.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
0007-0963
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
142
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
267-73
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10730759-Adolescent,
pubmed-meshheading:10730759-Adult,
pubmed-meshheading:10730759-Aged,
pubmed-meshheading:10730759-Aged, 80 and over,
pubmed-meshheading:10730759-Aging,
pubmed-meshheading:10730759-Child,
pubmed-meshheading:10730759-Child, Preschool,
pubmed-meshheading:10730759-Collagen,
pubmed-meshheading:10730759-Female,
pubmed-meshheading:10730759-Humans,
pubmed-meshheading:10730759-Immunophenotyping,
pubmed-meshheading:10730759-Infant,
pubmed-meshheading:10730759-Matrix Metalloproteinase 1,
pubmed-meshheading:10730759-Middle Aged,
pubmed-meshheading:10730759-Radiation Injuries,
pubmed-meshheading:10730759-Skin,
pubmed-meshheading:10730759-Skin Aging,
pubmed-meshheading:10730759-Sunlight,
pubmed-meshheading:10730759-T-Lymphocyte Subsets
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| pubmed:year |
2000
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| pubmed:articleTitle |
Histological increase in inflammatory infiltrate in sun-exposed skin of female subjects: the possible involvement of matrix metalloproteinase-1 produced by inflammatory infiltrate on collagen degradation.
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| pubmed:affiliation |
Biological Science Laboratories, Kao Corporation, Tochigi, Japan. 388831@kastanet.kao.co.jp
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| pubmed:publicationType |
Journal Article
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