Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2000-5-31
pubmed:abstractText
It is well established that transforming growth factor alpha is involved prenatally in development of the nervous system, but its role in the postnatal brain is less well understood. Here, we document the occurrence of late-onset, morphological and behavioral deficits in the naturally occurring murine mutant, Waved-1 (Wa-1), whose transforming growth factor alpha levels decrease naturally between early postnatal and adolescent ages. Morphological analyses suggest that reduction in the growth factor postnatally is associated temporally with the onset of enlarged lateral ventricles, a reduction in vasculature in the region of the amygdala and a reduction in size of the central nucleus. Onset of the morphological deficits corresponds to the appearance of a performance deficit in contextual fear conditioning. In contrast, the transforming growth factor alpha gene-targeted null mutants exhibit neither morphological nor performance deficits. These data suggest that transforming growth factor alpha during postnatal maturation of the brain may contribute to maintenance of limbic morphology and vasculature, which may in turn affect some behaviors associated with these specific brain structures.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0306-4522
pubmed:author
pubmed:issnType
Print
pubmed:volume
96
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
825-36
pubmed:dateRevised
2009-11-3
pubmed:meshHeading
pubmed-meshheading:10727800-Age Factors, pubmed-meshheading:10727800-Amygdala, pubmed-meshheading:10727800-Animals, pubmed-meshheading:10727800-Animals, Newborn, pubmed-meshheading:10727800-Auditory Pathways, pubmed-meshheading:10727800-Brain, pubmed-meshheading:10727800-Cerebral Arteries, pubmed-meshheading:10727800-Choline O-Acetyltransferase, pubmed-meshheading:10727800-Conditioning (Psychology), pubmed-meshheading:10727800-Fear, pubmed-meshheading:10727800-Hippocampus, pubmed-meshheading:10727800-Lateral Ventricles, pubmed-meshheading:10727800-Male, pubmed-meshheading:10727800-Mice, pubmed-meshheading:10727800-Mice, Inbred C57BL, pubmed-meshheading:10727800-Mice, Knockout, pubmed-meshheading:10727800-Mice, Mutant Strains, pubmed-meshheading:10727800-Motor Activity, pubmed-meshheading:10727800-Organ Size, pubmed-meshheading:10727800-Psychomotor Performance, pubmed-meshheading:10727800-Transforming Growth Factor alpha
pubmed:year
2000
pubmed:articleTitle
Postnatal decrease in transforming growth factor alpha is associated with enlarged ventricles, deficient amygdaloid vasculature and performance deficits.
pubmed:affiliation
Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh 15261, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't