Source:http://linkedlifedata.com/resource/pubmed/id/10718328
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2000-5-18
|
| pubmed:abstractText |
Genetic predisposition and environmental factors such as perinatal complications are believed to contribute to the etiology of schizophrenia, a disorder involving enhanced CNS dopaminergic activity. This study used a rat model to test whether genetic factors and a minor birth complication, i.e. Caesarean section (C-section) birth, interact in producing longterm effects on dopamine-mediated behavior. For this, we compared the effects of vaginal and C-section birth on amphetamine (AMPT)-induced locomotor activity in strains of rats differing in genetic composition. In Sprague-Dawley rats, C-section birth increased AMPT-induced locomotion compared with vaginal birth. By contrast in Lewis rats, C-section birth reduced AMPT-induced locomotion compared with vaginal birth. In Fischer rats, AMPT-induced locomotion was increased by C-section under maternal anesthesia but decreased by C-section after maternal decapitation, compared with vaginal birth. It is concluded that a minor birth complication like C-section can have differing long-term effects on dopaminergic function in the rat, depending on the genetic composition of the individual.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0959-4965
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
28
|
| pubmed:volume |
11
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
639-43
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:10718328-Amphetamine,
pubmed-meshheading:10718328-Anesthesia, Obstetrical,
pubmed-meshheading:10718328-Anesthetics, Inhalation,
pubmed-meshheading:10718328-Animals,
pubmed-meshheading:10718328-Cesarean Section,
pubmed-meshheading:10718328-Decerebrate State,
pubmed-meshheading:10718328-Delivery, Obstetric,
pubmed-meshheading:10718328-Dopamine,
pubmed-meshheading:10718328-Dopamine Uptake Inhibitors,
pubmed-meshheading:10718328-Female,
pubmed-meshheading:10718328-Isoflurane,
pubmed-meshheading:10718328-Labor, Obstetric,
pubmed-meshheading:10718328-Motor Activity,
pubmed-meshheading:10718328-Pregnancy,
pubmed-meshheading:10718328-Rats,
pubmed-meshheading:10718328-Rats, Inbred F344,
pubmed-meshheading:10718328-Rats, Inbred Lew,
pubmed-meshheading:10718328-Rats, Sprague-Dawley
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Genetic factors modulate effects of C-section birth on dopaminergic function in the rat.
|
| pubmed:affiliation |
Department of Psychiatry, McGill University, Douglas Hospital Research Centre, Verdun, Quebec, Canada.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|