Linked Life Data

10717408

Source:http://linkedlifedata.com/resource/pubmed/id/10717408

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2000-4-19
pubmed:abstractText
We examined the effect of continuous intracerebroventricular (i.c.v. ) administration of pentobarbital on the level of N-Methyl-D-aspartate receptor NR1 subunit mRNAs in different regions of rat brain by in situ hybridization histochemistry. Animals were rendered tolerant to pentobarbital by continuous i.c.v. infusion (300 microgram/10 microliter/h for 6 days) through pre-implanted cannulae connected to osmotic mini-pumps, and dependent, by abrupt withdrawal from pentobarbital. NR1 subunit mRNA level was significantly decreased in the entorhinal cortex, cingulate, caudate-putamen, septum, and the CA1 of hippocampus in pentobarbital withdrawal rats. The level of NR1 mRNAs was decreased in only CA1 of hippocampus in pentobarbital tolerant rats. These results indicate that withdrawal from i.c.v. infusion with pentobarbital decreases in NR1 subunit expression in the rat brain, suggesting that changes in expression of NR1 subunit may contribute to the development of withdrawal from pentobarbital.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
24
pubmed:volume
282
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
129-32
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
N-Methyl-D-aspartate receptor NR1 subunit mRNA level was decreased in rat brain during pentobarbital withdrawal.
pubmed:affiliation
Department of Pharmacology, University of Mississippi Medical Center, 2500 North State Street, Jackson, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.