Source:http://linkedlifedata.com/resource/pubmed/id/10716256
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2000-5-8
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pubmed:abstractText |
Overexpression of the pluripotent cytokine interleukin-1 (IL-1) by microglial cells correlates with formation of neuritic beta-amyloid plaques in Alzheimer's disease (AD). We evaluated polymorphisms in the genes coding for the IL-1alpha, IL-1beta, and IL-1 receptor antagonist cytokines, and tested their association with the occurrence and age at onset of sporadic AD. We found a strong association between the IL-1A T/T genotype and AD onset before 65 years of age (odds ratio, 4.86), with carriers of this genotype showing an onset of disease 9 years earlier than IL-1A C/C carriers. A weaker association with the age at onset was also shown for the IL-1B and IL-1RN genes. These data suggest either a direct effect of the IL-1 gene family, mainly IL-1A, on the clinical onset of AD, or a linkage dysequilibrium with an unknown locus relevant to AD on chromosome 2.
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pubmed:commentsCorrections | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0364-5134
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pubmed:author |
pubmed-author:AnnoniGG,
pubmed-author:BiunnoII,
pubmed-author:CanalNN,
pubmed-author:CasadeiV MVM,
pubmed-author:De BellisGG,
pubmed-author:FerriCC,
pubmed-author:FranceschiMM,
pubmed-author:GriffinW SWS,
pubmed-author:GrimaldiL MLM,
pubmed-author:LicastroFF,
pubmed-author:MarianiCC,
pubmed-author:SorbiSS,
pubmed-author:VegliaFF
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pubmed:issnType |
Print
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
361-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10716256-Adult,
pubmed-meshheading:10716256-Age of Onset,
pubmed-meshheading:10716256-Aged,
pubmed-meshheading:10716256-Aged, 80 and over,
pubmed-meshheading:10716256-Alzheimer Disease,
pubmed-meshheading:10716256-Female,
pubmed-meshheading:10716256-Genotype,
pubmed-meshheading:10716256-Humans,
pubmed-meshheading:10716256-Interleukin-1,
pubmed-meshheading:10716256-Male,
pubmed-meshheading:10716256-Middle Aged,
pubmed-meshheading:10716256-Polymorphism, Genetic,
pubmed-meshheading:10716256-Risk Factors
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pubmed:year |
2000
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pubmed:articleTitle |
Association of early-onset Alzheimer's disease with an interleukin-1alpha gene polymorphism.
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pubmed:affiliation |
Department of Neuroscience, University of Milano, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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