|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2000-3-16
|
|
pubmed:abstractText |
The wing imaginal disc is subdivided into two nonintermingling sets of cells, the anterior (A) and posterior (P) compartments. Anterior cells require reception of the Hedgehog (Hh) signal to segregate from P cells. We provide evidence that Hh signaling controls A/P cell segregation not by directly modifying structural components but by a Cubitus interruptus (Ci)-mediated transcriptional response. A shift in the balance between repressor and activator forms of Ci toward the activator form is necessary and sufficient to define "A-type" cell sorting behavior. Moreover, we show that Engrailed (En), in the absence of Ci, is sufficient to specify "P-type" sorting. We propose that the opposing transcriptional activities of Ci and En control cell segregation at the A/P boundary by regulating a single cell adhesion molecule.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Hedgehog Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Insect Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/ci protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/engrailed homeobox proteins,
http://linkedlifedata.com/resource/pubmed/chemical/hedgehog protein, Drosophila
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0092-8674
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
18
|
|
pubmed:volume |
100
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
411-22
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:10693758-Animals,
pubmed-meshheading:10693758-Animals, Genetically Modified,
pubmed-meshheading:10693758-Cell Adhesion,
pubmed-meshheading:10693758-Cell Movement,
pubmed-meshheading:10693758-DNA-Binding Proteins,
pubmed-meshheading:10693758-Drosophila,
pubmed-meshheading:10693758-Drosophila Proteins,
pubmed-meshheading:10693758-Hedgehog Proteins,
pubmed-meshheading:10693758-Homeodomain Proteins,
pubmed-meshheading:10693758-Insect Proteins,
pubmed-meshheading:10693758-Repressor Proteins,
pubmed-meshheading:10693758-Signal Transduction,
pubmed-meshheading:10693758-Trans-Activators,
pubmed-meshheading:10693758-Transcription, Genetic,
pubmed-meshheading:10693758-Transcription Factors,
pubmed-meshheading:10693758-Transformation, Genetic
|
|
pubmed:year |
2000
|
|
pubmed:articleTitle |
Opposing transcriptional outputs of Hedgehog signaling and engrailed control compartmental cell sorting at the Drosophila A/P boundary.
|
|
pubmed:affiliation |
Institut für Molekularbiologie, Universität Zürich, Switzerland.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
