Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2000-11-3
pubmed:abstractText
The human polyomavirus JC virus (JCV) is the etiologic agent of a fatal central nervous system (CNS) demyelinating disease known as progressive multifocal leukoencephalopathy (PML). PML occurs predominantly in immunosuppressed patients and has increased dramatically as a result of the AIDS pandemic. The major target cell of JCV infection and lytic replication in the CNS is the oligodendrocyte. The mechanisms by which JCV initiates and establishes infection of these glial cells are not understood. The initial interaction between JCV and glial cells involves virus binding to N-linked glycoproteins containing terminal alpha(2-6)-linked sialic acids. The subsequent steps of entry and targeting of the viral genome to the nucleus have not been described. In this report, we compare the kinetics and mechanisms of infectious entry of JCV into human glial cells with that of the related polyomavirus, simian virus 40 (SV40). We demonstrate that JCV, unlike SV40, enters glial cells by receptor-mediated clathrin-dependent endocytosis.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10666259-1310438, http://linkedlifedata.com/resource/pubmed/commentcorrection/10666259-1312619, http://linkedlifedata.com/resource/pubmed/commentcorrection/10666259-1325703, http://linkedlifedata.com/resource/pubmed/commentcorrection/10666259-16562087, http://linkedlifedata.com/resource/pubmed/commentcorrection/10666259-183018, http://linkedlifedata.com/resource/pubmed/commentcorrection/10666259-2148564, http://linkedlifedata.com/resource/pubmed/commentcorrection/10666259-215786, http://linkedlifedata.com/resource/pubmed/commentcorrection/10666259-2476575, http://linkedlifedata.com/resource/pubmed/commentcorrection/10666259-2543122, http://linkedlifedata.com/resource/pubmed/commentcorrection/10666259-2983332, http://linkedlifedata.com/resource/pubmed/commentcorrection/10666259-3005297, http://linkedlifedata.com/resource/pubmed/commentcorrection/10666259-3015426, http://linkedlifedata.com/resource/pubmed/commentcorrection/10666259-4097232, http://linkedlifedata.com/resource/pubmed/commentcorrection/10666259-8227128, http://linkedlifedata.com/resource/pubmed/commentcorrection/10666259-8248193, http://linkedlifedata.com/resource/pubmed/commentcorrection/10666259-8794345, http://linkedlifedata.com/resource/pubmed/commentcorrection/10666259-8930903, http://linkedlifedata.com/resource/pubmed/commentcorrection/10666259-9017594, http://linkedlifedata.com/resource/pubmed/commentcorrection/10666259-9222341, http://linkedlifedata.com/resource/pubmed/commentcorrection/10666259-9531011, http://linkedlifedata.com/resource/pubmed/commentcorrection/10666259-9573227, http://linkedlifedata.com/resource/pubmed/commentcorrection/10666259-9634090, http://linkedlifedata.com/resource/pubmed/commentcorrection/10666259-9882517
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-538X
pubmed:author
pubmed:issnType
Print
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2288-92
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
JC virus enters human glial cells by clathrin-dependent receptor-mediated endocytosis.
pubmed:affiliation
Department of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island 02912, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't