| pubmed-article:10642383 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10642383 | lifeskim:mentions | umls-concept:C0024128 | lld:lifeskim |
| pubmed-article:10642383 | lifeskim:mentions | umls-concept:C1280551 | lld:lifeskim |
| pubmed-article:10642383 | lifeskim:mentions | umls-concept:C0225730 | lld:lifeskim |
| pubmed-article:10642383 | lifeskim:mentions | umls-concept:C0234421 | lld:lifeskim |
| pubmed-article:10642383 | lifeskim:mentions | umls-concept:C2709248 | lld:lifeskim |
| pubmed-article:10642383 | lifeskim:mentions | umls-concept:C0079284 | lld:lifeskim |
| pubmed-article:10642383 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10642383 | pubmed:dateCreated | 2000-3-28 | lld:pubmed |
| pubmed-article:10642383 | pubmed:abstractText | We tested the hypothesis that regulation of the pulmonary circulation by endogenous endothelin (ET) during normoxia and hypoxia was altered in conscious dogs 1 mo after left lung autotransplantation (LLA). Sham-operated control and post-LLA dogs were chronically instrumented to measure the left pulmonary vascular pressure-flow (LP-Q) relationship. LP-Q plots were generated on separate days during normoxia and hypoxia (arterial PO(2) approximately 50 Torr) in the intact condition, after selective ET(A)-receptor inhibition (BQ-485), and after combined ET(A+B)-receptor inhibition (bosentan). Although LLA resulted in a chronic increase in pulmonary vascular resistance, the ET-receptor antagonists had no effect on the LP-Q relationship during normoxia in either group. The magnitude of hypoxic pulmonary vasoconstriction (HPV) was flow dependent in both groups, and the HPV response was potentiated post-LLA compared with control. ET(A)-receptor inhibition attenuated the HPV response to the same extent in both groups. ET(A+B)-receptor inhibition attenuated the HPV response to a greater extent than did ET(A)-receptor inhibition alone, and this effect was greater post-LLA compared with control. Plasma ET-1 concentration only increased during hypoxia in the LLA group. These results indicate that ET does not regulate the baseline LP-Q relationship in either group. Both ET(A)- and ET(B)-receptor activation mediate a component of HPV in conscious dogs, and the vasoconstrictor influence of ET(B)-receptor activation is enhanced post-LLA. | lld:pubmed |
| pubmed-article:10642383 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10642383 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10642383 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10642383 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10642383 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10642383 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10642383 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10642383 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10642383 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10642383 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10642383 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10642383 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10642383 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10642383 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:10642383 | pubmed:issn | 8750-7587 | lld:pubmed |
| pubmed-article:10642383 | pubmed:author | pubmed-author:MurrayP APA | lld:pubmed |
| pubmed-article:10642383 | pubmed:author | pubmed-author:DoiSS | lld:pubmed |
| pubmed-article:10642383 | pubmed:author | pubmed-author:SmediraNN | lld:pubmed |
| pubmed-article:10642383 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10642383 | pubmed:volume | 88 | lld:pubmed |
| pubmed-article:10642383 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10642383 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10642383 | pubmed:pagination | 210-8 | lld:pubmed |
| pubmed-article:10642383 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:10642383 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10642383 | pubmed:articleTitle | Pulmonary vasoregulation by endothelin in conscious dogs after left lung transplantation. | lld:pubmed |
| pubmed-article:10642383 | pubmed:affiliation | Center for Anesthesiology Research, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. | lld:pubmed |
| pubmed-article:10642383 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10642383 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10642383 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10642383 | lld:pubmed |
