Source:http://linkedlifedata.com/resource/pubmed/id/10642383
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2000-3-28
|
| pubmed:abstractText |
We tested the hypothesis that regulation of the pulmonary circulation by endogenous endothelin (ET) during normoxia and hypoxia was altered in conscious dogs 1 mo after left lung autotransplantation (LLA). Sham-operated control and post-LLA dogs were chronically instrumented to measure the left pulmonary vascular pressure-flow (LP-Q) relationship. LP-Q plots were generated on separate days during normoxia and hypoxia (arterial PO(2) approximately 50 Torr) in the intact condition, after selective ET(A)-receptor inhibition (BQ-485), and after combined ET(A+B)-receptor inhibition (bosentan). Although LLA resulted in a chronic increase in pulmonary vascular resistance, the ET-receptor antagonists had no effect on the LP-Q relationship during normoxia in either group. The magnitude of hypoxic pulmonary vasoconstriction (HPV) was flow dependent in both groups, and the HPV response was potentiated post-LLA compared with control. ET(A)-receptor inhibition attenuated the HPV response to the same extent in both groups. ET(A+B)-receptor inhibition attenuated the HPV response to a greater extent than did ET(A)-receptor inhibition alone, and this effect was greater post-LLA compared with control. Plasma ET-1 concentration only increased during hypoxia in the LLA group. These results indicate that ET does not regulate the baseline LP-Q relationship in either group. Both ET(A)- and ET(B)-receptor activation mediate a component of HPV in conscious dogs, and the vasoconstrictor influence of ET(B)-receptor activation is enhanced post-LLA.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Azepines,
http://linkedlifedata.com/resource/pubmed/chemical/BQ 485,
http://linkedlifedata.com/resource/pubmed/chemical/Carbon Dioxide,
http://linkedlifedata.com/resource/pubmed/chemical/Endothelin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Oxygen,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Endothelin,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/bosentan
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
8750-7587
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
88
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
210-8
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:10642383-Animals,
pubmed-meshheading:10642383-Anoxia,
pubmed-meshheading:10642383-Azepines,
pubmed-meshheading:10642383-Carbon Dioxide,
pubmed-meshheading:10642383-Consciousness,
pubmed-meshheading:10642383-Dogs,
pubmed-meshheading:10642383-Endothelin-1,
pubmed-meshheading:10642383-Hydrogen-Ion Concentration,
pubmed-meshheading:10642383-Lung,
pubmed-meshheading:10642383-Lung Transplantation,
pubmed-meshheading:10642383-Male,
pubmed-meshheading:10642383-Oligopeptides,
pubmed-meshheading:10642383-Oxygen,
pubmed-meshheading:10642383-Pulmonary Artery,
pubmed-meshheading:10642383-Pulmonary Circulation,
pubmed-meshheading:10642383-Receptors, Endothelin,
pubmed-meshheading:10642383-Respiration,
pubmed-meshheading:10642383-Sulfonamides,
pubmed-meshheading:10642383-Vascular Resistance,
pubmed-meshheading:10642383-Vasoconstriction
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Pulmonary vasoregulation by endothelin in conscious dogs after left lung transplantation.
|
| pubmed:affiliation |
Center for Anesthesiology Research, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|