Linked Life Data

10619635

Source:http://linkedlifedata.com/resource/pubmed/id/10619635

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
17
pubmed:dateCreated
2000-1-19
pubmed:abstractText
HIV infection frequently leads to neurological deficits and is associated with neuronal loss and damage. We have investigated two neurochemical indicators of the integrity of glutamatergic systems in brain tissue taken postmortem from the frontal cortex of AIDS patients and age-matched controls. NMDA receptor density was determined by saturation analysis of [3H]L-689,560 occupation of the glycine binding site, while saturable [3H]D-aspartate binding provided a marker of the glutamate uptake site. NMDA receptor density was significantly reduced by 33% in the AIDS group, an effect which was more profound in the demented patients, and ligand binding to the glutamate uptake site was significantly reduced by >50% in demented AIDS patients compared with the control group. These reported glutamatergic deficits are consistent with an NMDA-receptor mediated excitotoxic mechanism being responsible for the neuronal loss occurring in AIDS.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
26
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3513-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Deficits of NMDA receptors and glutamate uptake sites in the frontal cortex in AIDS.
pubmed:affiliation
Department of Biomedical Science, University of Sheffield, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't