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rdf:type |
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lifeskim:mentions |
umls-concept:C0007578,
umls-concept:C0017262,
umls-concept:C0037284,
umls-concept:C0063695,
umls-concept:C0078056,
umls-concept:C0115305,
umls-concept:C0185117,
umls-concept:C0409974,
umls-concept:C0441471,
umls-concept:C0449774,
umls-concept:C2911684
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pubmed:issue |
6
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pubmed:dateCreated |
2000-1-21
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pubmed:abstractText |
In our previous study, photoprovocation induced lupus erythematosus (LE) and polymorphous light eruption-like lesions in photosensitive LE patients. In this new study we examined the expression of ICAM-1, VCAM-1 and E-selectin, in early lesions in particular. A total of 32 patients with cutaneous LE, 25 with "classic" discoid LE, and 7 with systemic LE, including 3 patients with subacute cutaneous LE, were provoked with UVA and UVB on normal appearing skin. Induced lesions were followed up with serial biopsies. LE-like histopathology was seen within 1 week of provocation in some cases. Adhesion molecule expression was statistically significantly affected by the factors clinical diagnosis and wavelength (UVA or UVB). Strong keratinocyte ICAM-1 expression was found 1 week after provocation in reactions that eventually developed into long-standing ones. It is possible that these early changes reflect an underlying defect in the mechanisms that regulate adhesion molecule expression in LE.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0001-5555
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
431-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10598755-Adolescent,
pubmed-meshheading:10598755-Adult,
pubmed-meshheading:10598755-Aged,
pubmed-meshheading:10598755-Biological Markers,
pubmed-meshheading:10598755-Biopsy, Needle,
pubmed-meshheading:10598755-E-Selectin,
pubmed-meshheading:10598755-Female,
pubmed-meshheading:10598755-Humans,
pubmed-meshheading:10598755-Immunohistochemistry,
pubmed-meshheading:10598755-Intercellular Adhesion Molecule-1,
pubmed-meshheading:10598755-Lupus Erythematosus, Cutaneous,
pubmed-meshheading:10598755-Lupus Erythematosus, Discoid,
pubmed-meshheading:10598755-Lupus Erythematosus, Systemic,
pubmed-meshheading:10598755-Male,
pubmed-meshheading:10598755-Middle Aged,
pubmed-meshheading:10598755-Photosensitivity Disorders,
pubmed-meshheading:10598755-Prognosis,
pubmed-meshheading:10598755-Radiation Dosage,
pubmed-meshheading:10598755-Sensitivity and Specificity,
pubmed-meshheading:10598755-Skin,
pubmed-meshheading:10598755-Ultraviolet Rays,
pubmed-meshheading:10598755-Vascular Cell Adhesion Molecule-1
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pubmed:year |
1999
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pubmed:articleTitle |
Early events in ultraviolet light-induced skin lesions in lupus erythematosus: expression patterns of adhesion molecules ICAM-1, VCAM-1 and E-selectin.
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pubmed:affiliation |
Department of Dermatology, Karolinska Hospital and Institute, Stockholm, Sweden. inverness@beta.telenordia.se
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, Non-U.S. Gov't
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