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pubmed-article:10594514pubmed:abstractTextPatients with single allele defects in the gene encoding the type 1 IGF receptor have been reported to have growth failure, but fibroblasts from affected patients have not exhibited insensitivity to the effects of IGF-I in vitro. The in vitro and in vivo responses to short-term recombinant human IGF-I (rhIGF-I) in a severely growth-retarded girl with ring chromosome 15 and deletion of a single allele for the type 1 IGF receptor gene have been investigated.lld:pubmed
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pubmed-article:10594514pubmed:articleTitleIn vitro and in vivo responses to short-term recombinant human insulin-like growth factor-1 (IGF-I) in a severely growth-retarded girl with ring chromosome 15 and deletion of a single allele for the type 1 IGF receptor gene.lld:pubmed
pubmed-article:10594514pubmed:affiliationDepartment of Paediatrics, Federal University of Parana, Curitiba, Brazil. lacerda@hc.ufpr.brlld:pubmed
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