rdf:type |
|
lifeskim:mentions |
umls-concept:C0002085,
umls-concept:C0008657,
umls-concept:C0035639,
umls-concept:C0086418,
umls-concept:C0140079,
umls-concept:C0202220,
umls-concept:C0205082,
umls-concept:C0205171,
umls-concept:C0332307,
umls-concept:C0871261,
umls-concept:C1335671,
umls-concept:C1442161,
umls-concept:C1515655,
umls-concept:C1533691,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
|
pubmed:issue |
5
|
pubmed:dateCreated |
2000-4-11
|
pubmed:abstractText |
Patients with single allele defects in the gene encoding the type 1 IGF receptor have been reported to have growth failure, but fibroblasts from affected patients have not exhibited insensitivity to the effects of IGF-I in vitro. The in vitro and in vivo responses to short-term recombinant human IGF-I (rhIGF-I) in a severely growth-retarded girl with ring chromosome 15 and deletion of a single allele for the type 1 IGF receptor gene have been investigated.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Nov
|
pubmed:issn |
0300-0664
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
51
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
541-50
|
pubmed:dateRevised |
2011-8-25
|
pubmed:meshHeading |
pubmed-meshheading:10594514-Blotting, Southern,
pubmed-meshheading:10594514-Cells, Cultured,
pubmed-meshheading:10594514-Child, Preschool,
pubmed-meshheading:10594514-Chromosomes, Human, Pair 15,
pubmed-meshheading:10594514-Female,
pubmed-meshheading:10594514-Fibroblasts,
pubmed-meshheading:10594514-Gene Deletion,
pubmed-meshheading:10594514-Growth Disorders,
pubmed-meshheading:10594514-Growth Hormone,
pubmed-meshheading:10594514-Humans,
pubmed-meshheading:10594514-Insulin-Like Growth Factor I,
pubmed-meshheading:10594514-RNA, Messenger,
pubmed-meshheading:10594514-Receptor, IGF Type 1,
pubmed-meshheading:10594514-Recombinant Proteins,
pubmed-meshheading:10594514-Ring Chromosomes
|
pubmed:year |
1999
|
pubmed:articleTitle |
In vitro and in vivo responses to short-term recombinant human insulin-like growth factor-1 (IGF-I) in a severely growth-retarded girl with ring chromosome 15 and deletion of a single allele for the type 1 IGF receptor gene.
|
pubmed:affiliation |
Department of Paediatrics, Federal University of Parana, Curitiba, Brazil. lacerda@hc.ufpr.br
|
pubmed:publicationType |
Journal Article,
Case Reports
|