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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2000-1-4
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pubmed:abstractText |
Whereas ligation of the DNAM-1 adhesion molecule triggers cytotoxicity mediated by normal NK and T cells, this function was defective in NK cell clones from leukocyte adhesion deficiency syndrome. However, genetic reconstitution of cell surface expression of LFA-1 restored the ability of DNAM-1 to initiate anti-DNAM-1 mAb-induced cytotoxicity, indicating a functional relationship between DNAM-1 and LFA-1. Further studies demonstrated that LFA-1 physically associates with DNAM-1 in NK cells and anti-CD3 mAb stimulated T cells, for which serine phosphorylation of DNAM-1 plays a critical role. In addition, cross-linking of LFA-1 induces tyrosine phosphorylation of DNAM-1, for which the Fyn protein tyrosine kinase is responsible. These results indicate that DNAM-1 is involved in the LFA-1-mediated intracellular signals.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/CD226 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/FYN protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Fyn protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphocyte Function-Associated...,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoserine,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-fyn
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1074-7613
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
615-23
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10591186-Animals,
pubmed-meshheading:10591186-Antibodies, Monoclonal,
pubmed-meshheading:10591186-Antigens, CD3,
pubmed-meshheading:10591186-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:10591186-COS Cells,
pubmed-meshheading:10591186-Cell Adhesion,
pubmed-meshheading:10591186-Cell Adhesion Molecules,
pubmed-meshheading:10591186-Cercopithecus aethiops,
pubmed-meshheading:10591186-Cytotoxicity, Immunologic,
pubmed-meshheading:10591186-Genetic Complementation Test,
pubmed-meshheading:10591186-Humans,
pubmed-meshheading:10591186-Jurkat Cells,
pubmed-meshheading:10591186-Killer Cells, Natural,
pubmed-meshheading:10591186-Leukocyte-Adhesion Deficiency Syndrome,
pubmed-meshheading:10591186-Lymphocyte Activation,
pubmed-meshheading:10591186-Lymphocyte Function-Associated Antigen-1,
pubmed-meshheading:10591186-Mice,
pubmed-meshheading:10591186-Phosphorylation,
pubmed-meshheading:10591186-Phosphoserine,
pubmed-meshheading:10591186-Protein Processing, Post-Translational,
pubmed-meshheading:10591186-Proto-Oncogene Proteins,
pubmed-meshheading:10591186-Proto-Oncogene Proteins c-fyn,
pubmed-meshheading:10591186-Signal Transduction,
pubmed-meshheading:10591186-T-Lymphocytes,
pubmed-meshheading:10591186-Tumor Cells, Cultured
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pubmed:year |
1999
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pubmed:articleTitle |
Physical and functional association of LFA-1 with DNAM-1 adhesion molecule.
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pubmed:affiliation |
Department of Immunology, Institute of Basic Medical Sciences, Center for TARA, University of Tsukuba, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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