Source:http://linkedlifedata.com/resource/pubmed/id/10586051
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
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| pubmed:dateCreated |
2000-1-6
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| pubmed:abstractText |
Inactivation of genes encoding members of TNF and TNF receptor families reveal their divergent roles in the formation and function of secondary lymphoid organs. Most lymphotoxin alpha (ltalpha)- and all lymphotoxin beta receptor (ltbetar)-deficient mice are completely devoid of lymph nodes (LNs); however, most lymphotoxin beta (ltbeta)-deficient mice develop mesenteric LNs. Tnf- and tnfrp55-deficient mice develop a complete set of LNs, while ltbeta/tnfrp55 double-deficient mice lack all LNs, demonstrating cooperation between LTbeta and TNFRp55 in LN development. Now we report that ltbeta/tnf double-deficient mice develop the same set of mucosal LNs as do ltbeta-deficient mice, suggesting that ligands other than TNF signal through TNFRp55 during LN development. These LNs retain distinct T and B cells areas; however, they lack follicular dendritic cell networks. Structures resembling germinal centers can be found in the LNs from immunized ltbeta-deficient mice but not in ltbeta/tnf double-deficient mice. Additionally, stromal components of the spleen and LNs appear to be more severely disturbed in ltbeta/tnf double-deficient mice as compared with ltbeta-deficient mice. We conclude that LTbeta and TNF cooperate in the establishment of the correct microarchitecture of lymphoid organs.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Ltb protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphotoxin-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphotoxin-beta,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
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| pubmed:issn |
0022-1767
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
163
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
6575-80
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:10586051-Animals,
pubmed-meshheading:10586051-Cell Differentiation,
pubmed-meshheading:10586051-Crosses, Genetic,
pubmed-meshheading:10586051-Drug Synergism,
pubmed-meshheading:10586051-Embryonic and Fetal Development,
pubmed-meshheading:10586051-Lymph Nodes,
pubmed-meshheading:10586051-Lymphoid Tissue,
pubmed-meshheading:10586051-Lymphotoxin-alpha,
pubmed-meshheading:10586051-Lymphotoxin-beta,
pubmed-meshheading:10586051-Male,
pubmed-meshheading:10586051-Membrane Proteins,
pubmed-meshheading:10586051-Mice,
pubmed-meshheading:10586051-Mice, Inbred C57BL,
pubmed-meshheading:10586051-Mice, Mutant Strains,
pubmed-meshheading:10586051-Mice, Transgenic,
pubmed-meshheading:10586051-Signal Transduction,
pubmed-meshheading:10586051-Spleen,
pubmed-meshheading:10586051-Tumor Necrosis Factor-alpha
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| pubmed:year |
1999
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| pubmed:articleTitle |
TNF and lymphotoxin beta cooperate in the maintenance of secondary lymphoid tissue microarchitecture but not in the development of lymph nodes.
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| pubmed:affiliation |
Laboratory of Molecular Immunology, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow State University, Russia. kupras@imb.ac.ru
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|