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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
1999-12-14
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pubmed:abstractText |
Cyclooxygenase (COX)-inhibiting drugs have antitumor activity in canine and rodent models of urinary bladder cancer. Two isoenzymes of COX have been identified, COX-1 and COX-2. The purpose of this study was to characterize COX-1 and COX-2 expression in human invasive transitional cell carcinoma of the urinary bladder by immunohistochemistry and Western blot analysis. COX-2 was not expressed in normal urinary bladder samples but was detected in 25 of 29 (86%) invasive transitional cell carcinomas of the urinary bladder and in 6 of 8 (75%) cases of carcinoma in situ. These results indicate that COX-2 may play a role in bladder cancer in humans and support further study of COX-2 inhibitors as potential antitumor agents in human bladder cancer.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0008-5472
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5647-50
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10582676-Aged,
pubmed-meshheading:10582676-Blotting, Western,
pubmed-meshheading:10582676-Carcinoma, Transitional Cell,
pubmed-meshheading:10582676-Carcinoma in Situ,
pubmed-meshheading:10582676-Cyclooxygenase 1,
pubmed-meshheading:10582676-Cyclooxygenase 2,
pubmed-meshheading:10582676-Female,
pubmed-meshheading:10582676-Humans,
pubmed-meshheading:10582676-Immunohistochemistry,
pubmed-meshheading:10582676-Isoenzymes,
pubmed-meshheading:10582676-Male,
pubmed-meshheading:10582676-Membrane Proteins,
pubmed-meshheading:10582676-Middle Aged,
pubmed-meshheading:10582676-Neoplasm Proteins,
pubmed-meshheading:10582676-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:10582676-Urinary Bladder Neoplasms
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pubmed:year |
1999
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pubmed:articleTitle |
Expression of cyclooxygenase-2 (COX-2) in human invasive transitional cell carcinoma (TCC) of the urinary bladder.
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pubmed:affiliation |
Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, Indiana 47907, USA.
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pubmed:publicationType |
Journal Article
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