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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1999-12-13
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pubmed:abstractText |
Platelet-activating factor (PAF) and eicosanoids are putative mediators of septic shock that are associated with release of tumor necrosis factor (TNF). The purpose of this investigation was to a) examine temporal patterns of TNF and arachidonic acid metabolite release in a porcine model of bacteremic shock and b) selectively block PAF, thromboxane A2, prostacyclin, and leukotrienes to determine the relationships among these inflammatory response mediators and the alterations in cardiorespiratory dysfunction for which they are required.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Azepines,
http://linkedlifedata.com/resource/pubmed/chemical/Bicyclo Compounds, Heterocyclic,
http://linkedlifedata.com/resource/pubmed/chemical/Eicosanoids,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoxygenase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Nordihydroguaiaretic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Oxazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Oxygen,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet Activating Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/Thromboxane A2,
http://linkedlifedata.com/resource/pubmed/chemical/Triazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/WEB 2086,
http://linkedlifedata.com/resource/pubmed/chemical/ifetroban
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0090-3493
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2485-94
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:10579269-Aeromonas hydrophila,
pubmed-meshheading:10579269-Animals,
pubmed-meshheading:10579269-Arachidonic Acid,
pubmed-meshheading:10579269-Azepines,
pubmed-meshheading:10579269-Bicyclo Compounds, Heterocyclic,
pubmed-meshheading:10579269-Eicosanoids,
pubmed-meshheading:10579269-Female,
pubmed-meshheading:10579269-Gram-Negative Bacterial Infections,
pubmed-meshheading:10579269-Heart Diseases,
pubmed-meshheading:10579269-Hemodynamics,
pubmed-meshheading:10579269-Hypertension, Pulmonary,
pubmed-meshheading:10579269-Lipoxygenase Inhibitors,
pubmed-meshheading:10579269-Nordihydroguaiaretic Acid,
pubmed-meshheading:10579269-Oxazoles,
pubmed-meshheading:10579269-Oxygen,
pubmed-meshheading:10579269-Oxygen Consumption,
pubmed-meshheading:10579269-Platelet Activating Factor,
pubmed-meshheading:10579269-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:10579269-Shock, Septic,
pubmed-meshheading:10579269-Swine,
pubmed-meshheading:10579269-Thromboxane A2,
pubmed-meshheading:10579269-Triazoles,
pubmed-meshheading:10579269-Tumor Necrosis Factor-alpha
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pubmed:year |
1999
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pubmed:articleTitle |
Platelet-activating factor and arachidonic acid metabolites mediate tumor necrosis factor and eicosanoid kinetics and cardiopulmonary dysfunction during bacteremic shock.
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pubmed:affiliation |
Department of Surgery, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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