Linked Life Data

10564192

Source:http://linkedlifedata.com/resource/pubmed/id/10564192

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5 Pt 1
pubmed:dateCreated
1999-12-14
pubmed:abstractText
The immediate-early (IE) genes of human cytomegalovirus (CMV) can be expressed in monocytic cells and are known to regulate viral and cellular genes. Reactivation of human immunodeficiency virus (HIV-1) may be stimulated by a variety of factors including other viruses and inflammatory cytokines. These studies examine the role of hyperthermia and CMV in the regulation of HIV-1 and tumor necrosis factor (TNF)-alpha. THP-1 cells were transfected with the CMV IE genes. HIV-1 and TNF-alpha transcription were assessed with chloramphenicol acetyltransferase promoter constructs. Hyperthermia sufficient to stimulate production of heat shock proteins was used to stimulate the cells. Hyperthermia significantly enhances the effect of CMV IE gene products on the expression of HIV-1 and TNF-alpha. The increases in HIV-1 transcription appear to be in part due to increases in TNF-alpha. Heat shock proteins induced by hyperthermia may play an important role in the viral regulation of monocytic function by CMV.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
277
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
L1051-6
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Hyperthermia enhances cytomegalovirus regulation of HIV-1 and TNF-alpha gene expression.
pubmed:affiliation
Medical Research Service, Veterans Affairs Medical Center, Albuquerque, New Mexico 87108, USA. giwamoto@unm.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.