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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1999-12-6
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pubmed:abstractText |
The ras-mitogen-activated protein kinase (MAPK) cascade plays an important role not only in the mitogenic signal transduction pathway but also in the development of cancer, and it is believed to be one of the important regulators in normal hepatocytes and hepatocellular carcinoma. The aim of this study was to determine the role of insulin receptor substrate-1 and the MAPK cascade in rats with hepatocellular carcinoma induced by 3'-methyl-4-dimethylamino-azobenzene (3'-MeDAB).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0168-8278
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
725-33
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10551398-Animals,
pubmed-meshheading:10551398-Blotting, Northern,
pubmed-meshheading:10551398-Blotting, Western,
pubmed-meshheading:10551398-Carcinoma, Hepatocellular,
pubmed-meshheading:10551398-Insulin Receptor Substrate Proteins,
pubmed-meshheading:10551398-Liver,
pubmed-meshheading:10551398-Liver Neoplasms,
pubmed-meshheading:10551398-Male,
pubmed-meshheading:10551398-Methyldimethylaminoazobenzene,
pubmed-meshheading:10551398-Mitogen-Activated Protein Kinases,
pubmed-meshheading:10551398-Phosphoproteins,
pubmed-meshheading:10551398-Phosphorylation,
pubmed-meshheading:10551398-Rats,
pubmed-meshheading:10551398-Rats, Sprague-Dawley,
pubmed-meshheading:10551398-Reference Values,
pubmed-meshheading:10551398-Tyrosine
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pubmed:year |
1999
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pubmed:articleTitle |
Increased activity and expression of MAP kinase in HCC model rats induced by 3'-methyl-4-dimethylamino-azobenzene.
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pubmed:affiliation |
The Second Department of Internal Medicine, Chiba University School of Medicine, Japan.
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pubmed:publicationType |
Journal Article
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