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pubmed-article:10535608pubmed:abstractTextBased upon the clinical presentation of chronic fatigue syndrome (CFS), we hypothesized that proinflammatory cytokines may play a role in the pathogenesis of the disease. We therefore undertook a retrospective cross-sectional study to examine the role of TNF-alpha in patients with CFS. Our results suggest a significant increase serum TNF-alpha in patients with CFS (P<0.0001) compared to non-CFS controls. This study supports the further examination of the role of proinflammatory mediators in CFS. Furthermore, the clinical testing of TNF-alpha blockers and other antiinflammatory agents for the treatment of this disease is warranted.lld:pubmed
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pubmed-article:10535608pubmed:articleTitleTNF-alpha and chronic fatigue syndrome.lld:pubmed
pubmed-article:10535608pubmed:affiliationThe Immune Response Corporation, Carlsbad, California 92008, USA. shotdoc@imnr.comlld:pubmed
pubmed-article:10535608pubmed:publicationTypeJournal Articlelld:pubmed
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