|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0003451,
umls-concept:C0015576,
umls-concept:C0039194,
umls-concept:C0079411,
umls-concept:C0085358,
umls-concept:C0259309,
umls-concept:C0680022,
umls-concept:C0812246,
umls-concept:C0871261,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1456820,
umls-concept:C1704632,
umls-concept:C1706438,
umls-concept:C1706817,
umls-concept:C2698600,
umls-concept:C2911692
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
1999-11-19
|
|
pubmed:abstractText |
4-1BB (CD137) is a costimulatory molecule expressed on activated T cells and interacts with 4-1BB ligand (4-1BBL) on APCs. To investigate the role of 4-1BB costimulation for the development of primary immune responses, 4-1BBL-deficient (4-1BBL-/-) mice were infected with lymphocytic choriomeningitis virus (LCMV). 4-1BBL-/- mice were able to generate CTL and eliminate acute LCMV infection with normal kinetics, but CD8 T cell expansion was 2- to 3-fold lower than in wild-type (+/+) mice. In the same mice, virus-specific CD4 Th and B cell responses were minimally affected, indicating that 4-1BB costimulation preferentially affects CD8 T cell responses. This result contrasts with our earlier work with CD40L-deficient (CD40L-/-) mice, in which the CD8 T cell response was unaffected and the CD4 T cell response was markedly impaired. When both 4-1BBL- and B7-dependent signals were absent, CD8 T cell expansion was further reduced, resulting in lower CTL activity and impairing their ability to clear LCMV. Altogether, these results indicate that T cells have distinct costimulatory requirements: optimal CD8 responses require 4-1BBL-dependent interactions, whereas CD4 responses are minimally affected by 4-1BB costimulation, but require CD40-CD40L and B7-dependent interactions.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0022-1767
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
163
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
4859-68
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:10528187-4-1BB Ligand,
pubmed-meshheading:10528187-Animals,
pubmed-meshheading:10528187-Antigens, CD28,
pubmed-meshheading:10528187-Antigens, CD80,
pubmed-meshheading:10528187-B-Lymphocytes,
pubmed-meshheading:10528187-CD4-Positive T-Lymphocytes,
pubmed-meshheading:10528187-Immunity, Cellular,
pubmed-meshheading:10528187-Ligands,
pubmed-meshheading:10528187-Lymphocyte Activation,
pubmed-meshheading:10528187-Lymphocyte Count,
pubmed-meshheading:10528187-Lymphocytic Choriomeningitis,
pubmed-meshheading:10528187-Lymphocytic choriomeningitis virus,
pubmed-meshheading:10528187-Lymphopenia,
pubmed-meshheading:10528187-Mice,
pubmed-meshheading:10528187-Mice, Inbred C57BL,
pubmed-meshheading:10528187-Mice, Knockout,
pubmed-meshheading:10528187-Signal Transduction,
pubmed-meshheading:10528187-T-Lymphocytes,
pubmed-meshheading:10528187-Tumor Necrosis Factor-alpha
|
|
pubmed:year |
1999
|
|
pubmed:articleTitle |
4-1BB ligand, a member of the TNF family, is important for the generation of antiviral CD8 T cell responses.
|
|
pubmed:affiliation |
The Carlos and Marguerite Mason Transplantation Biology Research Center, Department of Surgery, Emory University School of Medicine, Atlanta, GA 30322, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
