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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1999-12-23
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pubmed:abstractText |
Influenza virus RNA polymerase with the subunit composition of PB1-PB2-PA is a unique multifunctional enzyme with the activities of both synthesis and cleavage of RNA, and is involved in both transcription and replication of the RNA genome. Transcription is initiated by using capped RNA fragments, which are generated after cleavage of host cell mRNA by the RNA polymerase-associated capped RNA endonuclease. To identify the RNA cap 1-binding site on the RNA polymerase, viral ribonucleoprotein (RNP) cores were subjected to UV-crosslinking with RNA which was labelled with 32P only at the cap-1 structure.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Directed RNA Polymerases,
http://linkedlifedata.com/resource/pubmed/chemical/Endonucleases,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Transferase,
http://linkedlifedata.com/resource/pubmed/chemical/PB2 protein, Influenzavirus A,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/RNA Caps,
http://linkedlifedata.com/resource/pubmed/chemical/RNA Replicase,
http://linkedlifedata.com/resource/pubmed/chemical/TNF Receptor-Associated Factor 3,
http://linkedlifedata.com/resource/pubmed/chemical/TRAF3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor...,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1356-9597
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
475-85
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:10526235-Carrier Proteins,
pubmed-meshheading:10526235-DNA-Directed RNA Polymerases,
pubmed-meshheading:10526235-Endonucleases,
pubmed-meshheading:10526235-Glutathione Transferase,
pubmed-meshheading:10526235-Kinetics,
pubmed-meshheading:10526235-Models, Genetic,
pubmed-meshheading:10526235-Orthomyxoviridae,
pubmed-meshheading:10526235-RNA, Viral,
pubmed-meshheading:10526235-RNA Caps,
pubmed-meshheading:10526235-RNA Replicase,
pubmed-meshheading:10526235-TNF Receptor-Associated Factor 3,
pubmed-meshheading:10526235-Tumor Necrosis Factor Receptor-Associated Peptides and...,
pubmed-meshheading:10526235-Ultraviolet Rays,
pubmed-meshheading:10526235-Viral Proteins
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pubmed:year |
1999
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pubmed:articleTitle |
Two separate sequences of PB2 subunit constitute the RNA cap-binding site of influenza virus RNA polymerase.
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pubmed:affiliation |
Department of Molecular Genetics, National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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