Source:http://linkedlifedata.com/resource/pubmed/id/10515819
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1999-12-9
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pubmed:abstractText |
Plasma endotoxin and lipopolysaccharide-binding protein (LBP) levels were measured in a group of 253 patients at the onset of severe sepsis and/or septic shock. Endotoxin levels were significantly greater than control levels (n=33; mean +/- SD, 5.1+/-7.3 pg/mL) in 78.3% of patients. Median endotoxin levels in patients with sepsis were 300 pg/mL (25%-75% interquartile range, 110-726 pg/mL). LBP levels were elevated in 97% of patients compared with normal control values of 4.1+/-1.65 microgram/mL. Median LBP levels in patients with sepsis were 31.2 microgram/mL (interquartile range, 22.5-47.7 microgram/mL). Median endotoxin levels at study entry were more highly elevated (515 vs. 230 pg/mL; P<.01), and LBP levels were less highly elevated (28.0 vs. 33.2 microgram/mL; P<.05) in nonsurvivors than survivors over the 28-day study period. No correlation was found between endotoxin and LBP levels. The quantitative level of both endotoxin and LBP may have prognostic significance in patients with severe sepsis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acute-Phase Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Endotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/lipopolysaccharide-binding protein
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-1899
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
180
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1584-9
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:10515819-Acute-Phase Proteins,
pubmed-meshheading:10515819-Adult,
pubmed-meshheading:10515819-Aged,
pubmed-meshheading:10515819-Bacteremia,
pubmed-meshheading:10515819-Carrier Proteins,
pubmed-meshheading:10515819-Endotoxins,
pubmed-meshheading:10515819-Female,
pubmed-meshheading:10515819-Fungemia,
pubmed-meshheading:10515819-Humans,
pubmed-meshheading:10515819-Lipopolysaccharides,
pubmed-meshheading:10515819-Male,
pubmed-meshheading:10515819-Membrane Glycoproteins,
pubmed-meshheading:10515819-Middle Aged,
pubmed-meshheading:10515819-Prognosis,
pubmed-meshheading:10515819-Shock, Septic
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pubmed:year |
1999
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pubmed:articleTitle |
Relationship between plasma levels of lipopolysaccharide (LPS) and LPS-binding protein in patients with severe sepsis and septic shock.
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pubmed:affiliation |
Infectious Disease Division, Brown University School of Medicine and Memorial Hospital of Rhode Island, Providence, Rhode Island 02860, USA. Steven_Opal@brown.edu
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pubmed:publicationType |
Journal Article,
Multicenter Study
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