|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1999-10-19
|
|
pubmed:abstractText |
The Friend virus susceptibility 2 (Fv2) locus encodes a dominant host factor that confers susceptibility to Friend virus-induced erythroleukaemia in mice. We mapped Fv2 to a 1.0-Mb interval that also contained the gene (Ron) encoding the stem cell kinase receptor (Stk). A truncated form of Stk (Sf-stk), which was the most abundant form of Stk in Fv2-sensitive (Fv2ss) erythroid cells, was not expressed in Fv2 resistant (Fv2rr) cells. Enforced expression of Sf-stk conferred susceptibility to Friend disease, whereas targeted disruption of Ron caused resistance. We conclude that the Fv2 locus encodes Ron, and that a naturally expressed, truncated form of Stk confers susceptibility to Friend virus-induced erythroleukaemia.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
1061-4036
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
23
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
159-65
|
|
pubmed:dateRevised |
2011-5-9
|
|
pubmed:meshHeading |
pubmed-meshheading:10508511-3T3 Cells,
pubmed-meshheading:10508511-Animals,
pubmed-meshheading:10508511-Base Sequence,
pubmed-meshheading:10508511-Chromosome Mapping,
pubmed-meshheading:10508511-Cloning, Molecular,
pubmed-meshheading:10508511-Contig Mapping,
pubmed-meshheading:10508511-Friend murine leukemia virus,
pubmed-meshheading:10508511-Gene Expression,
pubmed-meshheading:10508511-Genetic Predisposition to Disease,
pubmed-meshheading:10508511-Leukemia, Erythroblastic, Acute,
pubmed-meshheading:10508511-Mice,
pubmed-meshheading:10508511-Mice, Inbred AKR,
pubmed-meshheading:10508511-Mice, Inbred BALB C,
pubmed-meshheading:10508511-Mice, Inbred C3H,
pubmed-meshheading:10508511-Mice, Inbred CBA,
pubmed-meshheading:10508511-Mice, Inbred NZB,
pubmed-meshheading:10508511-Mice, Inbred Strains,
pubmed-meshheading:10508511-Molecular Sequence Data,
pubmed-meshheading:10508511-Muridae,
pubmed-meshheading:10508511-Protein Isoforms,
pubmed-meshheading:10508511-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:10508511-Receptors, Cell Surface,
pubmed-meshheading:10508511-Retroviridae Infections,
pubmed-meshheading:10508511-Species Specificity,
pubmed-meshheading:10508511-Spleen,
pubmed-meshheading:10508511-Tumor Virus Infections
|
|
pubmed:year |
1999
|
|
pubmed:articleTitle |
Fv2 encodes a truncated form of the Stk receptor tyrosine kinase.
|
|
pubmed:affiliation |
Department of Experimental Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
