Linked Life Data

10489842

Source:http://linkedlifedata.com/resource/pubmed/id/10489842

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1999-10-21
pubmed:abstractText
The role of cellular immunity in disease severity in respiratory syncytial virus (RSV) bronchiolitis is largely unknown. This study investigated the association between disease severity and systemic cytokine responses in hospitalized ventilated and nonventilated RSV bronchiolitis patients. In whole blood cultures stimulated with phytohaemagglutinin (PHA), lymphoproliferative responses and interferon (IFN)-gamma and interleukin (IL)-4 production during acute illness were measured. In addition, plasma cytokines were measured. Measurements were repeated in the convalescent phase, 3-4 weeks after admission. Fifty patients were included. The median age in ventilaled patients was significantly lower than in nonventilated patients (1 versus 4 months, p<0.05). In comparison with nonventilated patients, the ventilated patients had significantly lower lymphoproliferative responses and a lower production of IFN-gamma and IL-4. In fact, IFN-gamma and IL-4 production in ventilated patients was almost completely undetectable. Plasma IL-8 levels in ventilated patients were significantly higher than in nonventilated patients. In the convalescent phase, lymphoproliferative and cytokine responses as well as plasma IL-8 levels were normal in both patient groups. Since RSV bronchiolitis is associated with the subsequent development of asthma, the possible skewing of the T-helper (Th1/Th2) cytokine balance was investigated. This was found neither in the acute nor in the convalescent phase. In conclusion, the data indicate that depressed lymphocyte function and elevated plasma interleukin-8 levels are markers of severe disease. It is suggested that age and maturation related immune mechanisms could explain the occurrence of severe respiratory syncytial virus bronchiolitis requiring mechanical ventilation in young infants.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0903-1936
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
144-9
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:10489842-Antibodies, Viral, pubmed-meshheading:10489842-Biological Markers, pubmed-meshheading:10489842-Bronchiolitis, Viral, pubmed-meshheading:10489842-Cells, Cultured, pubmed-meshheading:10489842-Female, pubmed-meshheading:10489842-Humans, pubmed-meshheading:10489842-Infant, pubmed-meshheading:10489842-Infant, Newborn, pubmed-meshheading:10489842-Interferon-gamma, pubmed-meshheading:10489842-Interleukin-12, pubmed-meshheading:10489842-Interleukin-4, pubmed-meshheading:10489842-Interleukin-8, pubmed-meshheading:10489842-Male, pubmed-meshheading:10489842-Phytohemagglutinins, pubmed-meshheading:10489842-Respiratory Syncytial Virus Infections, pubmed-meshheading:10489842-Respiratory Syncytial Viruses, pubmed-meshheading:10489842-Severity of Illness Index, pubmed-meshheading:10489842-Th1 Cells, pubmed-meshheading:10489842-Th2 Cells
pubmed:year
1999
pubmed:articleTitle
Peripheral blood cytokine responses and disease severity in respiratory syncytial virus bronchiolitis.
pubmed:affiliation
University Hospital for Children and Youth Het Wilhelmina Kinderziekenhuis, Utrecht, The Netherlands.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Research Support, Non-U.S. Gov't, Multicenter Study