Linked Life Data

10479449

Source:http://linkedlifedata.com/resource/pubmed/id/10479449

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1999-10-20
pubmed:abstractText
The proper pathfinding and target recognition of an axon requires the precisely choreographed expression of a multitude of guidance factors: instructive and permissive, positive and negative, and secreted and membrane bound. We show here that the transcription factor LOLA is required for pathfinding and targeting of the SNb motor nerve in Drosophila. We also show that lola is a dose-dependent regulator of SNb development: by varying the expression of one lola isoform we can progressively titrate the extent of interaction of SNb motor axons with their target muscles, from no interaction at all, through wild-type patterning, to apparent hyperinnervation. The phenotypes we observe from altered expression of LOLA suggest that this protein may help orchestrate the coordinated expression of the genes required for faithful SNb development.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0012-1606
pubmed:author
pubmed:copyrightInfo
Copyright 1999 Academic Press.
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
213
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
301-13
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
LOLA has the properties of a master regulator of axon-target interaction for SNb motor axons of Drosophila.
pubmed:affiliation
Division of Basic Sciences, Program in Developmental Biology, Seattle, Washington, 98109, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.