|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0109317,
umls-concept:C0332291,
umls-concept:C0752312,
umls-concept:C0851827,
umls-concept:C1150579,
umls-concept:C1333340,
umls-concept:C1366882,
umls-concept:C1370600,
umls-concept:C1419742,
umls-concept:C1546857,
umls-concept:C1701901,
umls-concept:C1705767,
umls-concept:C1705791,
umls-concept:C1710082,
umls-concept:C1879547
|
|
pubmed:issue |
15
|
|
pubmed:dateCreated |
1999-11-1
|
|
pubmed:abstractText |
The rsk1 gene encodes the 90 kDa ribosomal S6 kinase 1 (RSK1) protein, which contains two kinase domains. RSK1, which is involved in regulating cell survival and proliferation, lies at the end of the signaling cascade mediated by the extracellular signal-regulated kinase (ERK) subfamily of mitogen-activated protein (MAP) kinases. ERK activation and subsequent phosphorylation of the RSK1 carboxy-terminal catalytic loop stimulates phosphotransferase activity in the RSK1 amino-terminal kinase domain. When activated, RSK1 phosphorylates both nuclear and cytoplasmic substrates through this amino-terminal catalytic domain. It is thought that stimulation of the ERK/MAP kinase pathway is sufficient for RSK1 activation, but how ERK phosphorylation activates the RSK1 amino-terminal kinase domain is not known.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0960-9822
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
9
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
810-20
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:10469565-Amino Acid Sequence,
pubmed-meshheading:10469565-Binding Sites,
pubmed-meshheading:10469565-Cell Line,
pubmed-meshheading:10469565-Enzyme Activation,
pubmed-meshheading:10469565-Humans,
pubmed-meshheading:10469565-Mitogen-Activated Protein Kinases,
pubmed-meshheading:10469565-Phosphorylation,
pubmed-meshheading:10469565-Protein-Serine-Threonine Kinases,
pubmed-meshheading:10469565-Recombinant Fusion Proteins,
pubmed-meshheading:10469565-Ribosomal Protein S6 Kinases,
pubmed-meshheading:10469565-Signal Transduction
|
|
pubmed:articleTitle |
Ribosomal S6 kinase 1 (RSK1) activation requires signals dependent on and independent of the MAP kinase ERK.
|
|
pubmed:affiliation |
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA.
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
