Source:http://linkedlifedata.com/resource/pubmed/id/10465544
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
15
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pubmed:dateCreated |
1999-11-24
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pubmed:abstractText |
The effects of functional group changes on the metabolism of novel quinolinequinones by recombinant human NAD(P)H:quinone oxidoreductase (NQO1) are described. Overall, the quinolinequinones were much better substrates for NQO1 than analogous indolequinones, with compounds containing heterocyclic substituents at C-2 being among the best substrates.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0960-894X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2195-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10465544-Antineoplastic Agents,
pubmed-meshheading:10465544-Humans,
pubmed-meshheading:10465544-NADH, NADPH Oxidoreductases,
pubmed-meshheading:10465544-Quinolones,
pubmed-meshheading:10465544-Recombinant Proteins,
pubmed-meshheading:10465544-Structure-Activity Relationship,
pubmed-meshheading:10465544-Substrate Specificity
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pubmed:year |
1999
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pubmed:articleTitle |
Novel quinolinequinone antitumor agents: structure-metabolism studies with NAD(P)H:quinone oxidoreductase (NQO1).
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pubmed:affiliation |
School of Chemistry, University of Exeter, Devon, UK.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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